Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Lymphocyte Population Kinetics

  • Véronique Thomas-VaslinEmail author
  • Adrien Six
  • Bertrand Bellier
  • David Klatzmann
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_713



Lymphocyte population kinetics refers to the behavior of cells, how cells differentiate, mature or migrate with time, and how they fluctuate to external influences.

Lymphocyte kinetics and homeostasis of lymphoid compartments have been explored in various context for B (Freitas et al. 1986) or T lymphocytes (Thomas-Vaslin et al. 2008; Callard and Hodgkin 2007).

Lymphocyte population kinetics allows to follow growth and decay of cell populations as a function of time. Lymphocyte percentages and numbers can be followed overtime in a single individual (patient, mouse, etc), after transfer, cell depletion, treatments, etc.

Examples of typical observed data are provided in Figs.  1 and 2and the possible interpretations are given below. The kinetics of an identified lymphocyte population can be more complex than...
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  1. Callard R, Hodgkin P (2007) Modeling T- and B-cell growth and differentiation. Immunol Rev 216:119–129PubMedGoogle Scholar
  2. Freitas AA, Rocha B et al (1986) Lymphocyte population kinetics in mice. Immunol Rev 91:5–37PubMedCrossRefGoogle Scholar
  3. Thomas-Vaslin V, Altes HK et al (2008) Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. J Immunol 180(4):2240–2250PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Véronique Thomas-Vaslin
    • 1
    Email author
  • Adrien Six
    • 1
  • Bertrand Bellier
    • 1
  • David Klatzmann
    • 1
  1. 1.Immunology-Immunopathology-ImmunotherapyUPMC University Paris 06, UMR7211, CNRS, UMR7211, INSERM, U959ParisFrance