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Life span, turnover, and residence time have been explored experimentally in various context for T or B cells (Tough and Sprent 1995; Fulcher and Basten 1997), and a lot of these parameter values were obtained from a mathematical model for T cell differentiation and dynamics (Thomas-Vaslin et al. 2008).
Life span and turnover can be interpreted as illustrated in Fig. 1.
Cell life span, cell population life span, and cell population turnover: This schema represents three scales of investigation/modeling respectively at the level of individual cell, cell population, organ/tissue. Daughter cells (dark blue) are different from mother cell (blue) in particular following DNA labeling. Cell death is represented by dashed cells
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References
Fulcher DA, Basten A (1997) B cell life span: a review. Immunol Cell Biol 75(5):446–455
Thomas-Vaslin V, Altes HK et al (2008) Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. J Immunol 180(4):2240–2250
Tough DF, Sprent J (1995) Life span of naive and memory T cells. Stem Cells 13(3):242–249
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Thomas-Vaslin, V., Six, A., Bellier, B., Klatzmann, D. (2013). Life Span, Turnover, Residence Time. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_712
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_712
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