Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Life Span, Turnover, Residence Time

  • Véronique Thomas-VaslinEmail author
  • Adrien Six
  • Bertrand Bellier
  • David Klatzmann
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_712

Synonyms

Definition

Life span, turnover, and residence time have been explored experimentally in various context for T or B cells (Tough and Sprent 1995; Fulcher and Basten 1997), and a lot of these parameter values were obtained from a mathematical model for T cell differentiation and dynamics (Thomas-Vaslin et al. 2008).

Life span and turnover can be interpreted as illustrated in Fig.  1.
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References

  1. Fulcher DA, Basten A (1997) B cell life span: a review. Immunol Cell Biol 75(5):446–455PubMedCrossRefGoogle Scholar
  2. Thomas-Vaslin V, Altes HK et al (2008) Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis. J Immunol 180(4):2240–2250PubMedGoogle Scholar
  3. Tough DF, Sprent J (1995) Life span of naive and memory T cells. Stem Cells 13(3):242–249PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Véronique Thomas-Vaslin
    • 1
    Email author
  • Adrien Six
    • 1
  • Bertrand Bellier
    • 1
  • David Klatzmann
    • 1
  1. 1.Immunology-Immunopathology-ImmunotherapyUPMC University Paris 06, UMR7211, CNRS, UMR7211, INSERM, U959ParisFrance