Systems Pharmacology, Drug Disease Interactions
Relationships between drugs and pathologies can be characterized in a comprehensive manner by interaction networks, giving a global view of drug disease interactions.
The relationships between drugs and diseases are complex. In the classical view, a particular drug used to be associated to a particular molecular target and to a particular treatment. However, cellular systems are highly interconnected by nature and this view is therefore incomplete. To obtain a comprehensive description of interactions between drugs, targets, and diseases, integrated approaches are needed where the relationships between all these components can be analyzed globally. Network approaches enable such analyses and have the potential to better explain the influence of drugs on diseases, as well as to understand interdependencies between drugs themselves (Spiro et al. 2008).
Network representations of drug–disease interactions necessitate...
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