Gene Association and Linkage Analysis
Synonyms
Definition
Gene association is the association between a genetic variation (genotype, haplotype, or single nucleotide polymorphism (SNP)) and a physical trait (phenotype), typically the presence or absence of a disease. Linkage analysis is the study of gene association due to their proximity on the same chromosome.
Characteristics
Genetic linkage is the tendency of gene loci or alleles to be inherited together due to their physical proximity on the same chromosome. This proximity causes them to stay together during meiosis, and they are therefore genetically linked. Genetic association tests are used to find genetic linkage between a genetic trait or polymorphism and a physical trait or phenotype such as a disease (de Bakker et al. 2005). A similar term to genetic linkage with a different meaning is linkage disequilibrium, a term used in the study of population...
References
- de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D (2005) Efficiency and power in genetic association studies. Nat Genet 37(11):1217–1223PubMedGoogle Scholar
- Manolio TA, Guttmacher AE, Manolio TA (2010) Genomewide association studies and assessment of the risk of disease. N Engl J Med 363(2):166–176PubMedGoogle Scholar
- Sen S, Churchill GA (2001) A statistical framework for quantitative trait mapping. Genetics 159:371–387PubMedGoogle Scholar
- Spielman RS, Ewens WJ (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59(5):983–989, PMC 1914831PubMedGoogle Scholar
- Terwilliger JD, Ott J (1994) Handbook of human genetic linkage. Johns Hopkins Press, BaltimoreGoogle Scholar