Encyclopedia of Systems Biology

Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Vaccine Antigen Databases

  • Hifzur Rahman Ansari
  • Darren R. Flower
  • Gajendra Raghava
DOI: https://doi.org/10.1007/978-1-4419-9863-7_111

Definition

Vaccine is a substance that trains the host immune system to protect itself against a pathogen. Vaccine antigen databases are compilations of different types of resources directly or indirectly leading to the development of vaccines. In order to train, a variety of antigens are used to activate different arms of immune system such as B- and T-cell epitopes, and innate immune components. This entry describes databases of various components of the immune system used to design a vaccine.

Characteristics

Vaccine Antigen Databases

MHCBN

Updated version 4.0 of the MHCBN (Lata et al. 2009) contains more than 25,000 experimentally characterized T-cell and MHC binding peptides with affinity and activity data compiled from ∼1,500 literatures and other public databases. Coverage of ∼1,000 transport-associated antigenprocessing (TAP) and ∼4,000 MHC non-binder peptides put MHCBN at a position distinct from other similar immunological databases. Database covers all major hosts like...

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References

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Hifzur Rahman Ansari
    • 1
  • Darren R. Flower
    • 2
  • Gajendra Raghava
    • 1
  1. 1.Bioinformatics CentreInstitute of Microbial Technology, ChandigarhChandigarhIndia
  2. 2.School of Life and Health SciencesAston UniversityBirminghamUK