Synonyms
Definition
Metabolic pathway analysis, a methodology used in metabolic pathway modeling, assesses inherent network properties and identifies meaningful structural and functional units in the metabolic networks (Klamt et al. 2003). Elementary flux modes (EFMs) and extreme pathways are the most promising approaches in MPA which is based on Convex Analysis. MPA can be used to study meaningful pathways (routes) and flexibility in metabolic networks. It is feasible to identify futile cycles and all (sub) optimal pathways related to the production of a metabolite in the network. The main applications of these approaches include metabolic network analysis, and analysis of robustness and identification of target genes in metabolic engineering.
Characteristics
Elementary Flux Modes (EFMs)
An EFM is defined as a minimal set of enzymes (participating reactions) that function at steady state with irreversible reactions proceeding in appropriate directions, a...
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References
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Rajvanshi, M., Venkatesh, K.V. (2013). Metabolic Pathway Analysis. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_1083
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_1083
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