Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Metabolic Pathway Analysis

  • Meghna Rajvanshi
  • Kareenhalli V. Venkatesh
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1083

Synonyms

Definition

Metabolic pathway analysis, a methodology used in  metabolic pathway modeling, assesses inherent network properties and identifies meaningful structural and functional units in the metabolic networks (Klamt et al. 2003). Elementary flux modes (EFMs) and extreme pathways are the most promising approaches in MPA which is based on Convex Analysis. MPA can be used to study meaningful pathways (routes) and flexibility in metabolic networks. It is feasible to identify futile cycles and all (sub) optimal pathways related to the production of a metabolite in the network. The main applications of these approaches include metabolic network analysis, and analysis of  robustness and identification of target genes in metabolic engineering.

Characteristics

Elementary Flux Modes (EFMs)

An EFM is defined as a minimal set of enzymes (participating reactions) that function at steady state with irreversible reactions proceeding in appropriate...
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References

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Meghna Rajvanshi
    • 1
  • Kareenhalli V. Venkatesh
    • 1
  1. 1.Department of Chemical EngineeringIndian Institute of Technology BombayPowai, MumbaiIndia