Reference Work Entry

Encyclopedia of Applied Electrochemistry

pp 1304-1309


Modeling and Simulation of Biosensors

  • Romas BaronasAffiliated withFaculty of Mathematics and Informatics, Vilnius University Email author 
  • , Juozas KulysAffiliated withDepartment of Chemistry and Bioengineering, Vilnius Gediminas Technical University


Biosensors are analytical devices in which specific recognition of the chemical substances is performed by biological material. The biological material that serves as recognition element is used in combination with a transducer. The transducer transforms concentration of substrate or product to electrical signal that is amplified and further processed. The biosensors may utilize enzymes, antibodies, nucleic acids, organelles, plant and animal tissue, whole organism, or organs [13]. Biosensors containing biological catalysts (enzymes) are called catalytical biosensors. Biosensors of this type are the most abundant, and they found the largest application in medicine, ecology, and environmental monitoring [4, 5].

The action of catalytical biosensors is associated with substrate diffusion into biocatalytical membrane and its conversion to a product. The simulation of biosensor action includes solving the diffusion equations for substrate and product with a term cont ...

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