Substance use is a term used to describe the use of mind altering or psychoactive substances in a way that does not cause physical or psychological dependence or addiction. Substance use in immigrants is complicated by differing laws, customs, mores, and traditions between the culture of origin and the nation where immigrants reside, and this can cause legal and personal difficulties when immigrants use substances that may not be accepted in their new homes. Individuals’ usage of these chemicals may have diverse and complicated impacts, which may be additionally complicated by the immigrants’ socioeconomic and legal status in the new nation, as well as the immigrant’s ability to acculturate outside of the home. The following is a short discussion of some substances used in immigrant communities, and their implications for health in the context of immigration.