Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

Notch (Notch1, Notch2, Notch3, Notch4)

  • Gibeom Park
  • Woong-Yang ParkEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_509


Historical Background

Notch mutants in Drosophila melanogaster were originally reported in 1919 (Morgan and Bridges 1919). Notch was named based on the Drosophila melanogaster mutants that exhibited irregular notches of missing tissue at the tips of their wing blades. This phenotype was caused by heterozygous loss-of-function mutations in a gene subsequently named “Notch” that was cloned in 1983 (Artavanis-Tsakonas et al. 1983).

Notch and Notch Signaling

Notch proteins are single-pass transmembrane receptors that mediate cell-to-cell communications for the regulation of cell fate decisions during developmental stages and also adult life. Notch receptors are highly conserved in throughout evolution and are found in a diverse range of organisms from worms to humans. The Notch family includes four receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4. These receptors have an extracellular domain that contains multiple epidermal growth factor...
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This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs (A084022) and BRL (Basic Research Laboratory) program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010–0001200).


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Biomedical SciencesSeoul National University College of MedicineJongnoguSouth Korea