Kyphosis
Historical vignette
W Haacke assumed in 1893 (Biol. Zbl. 13:525) that the waltzing - walking traits of mice are located in cytoplasmic elements (centrosome) whereas coat color (white-gray) segregation is assured by the reductional division of the chromosomes. (“I do not know whether the number of chromosomes present in mice had been recorded, but this number would enable us to establish the possible combinations”.) The fact that he was able to obtain experimentally all 16 combinations of these 4 traits seemed to indicate to him the validity of this interpretation. Although C Correns and independently E Baur (Zeitschr. Ind. Abst. Vererb.-Lehre 1:291 and 330, respectively) reported genuine cytoplasmic inheritance in 1909, and their findings were abundantly confirmed, John R Preer, Jr., an eminent contributor to the field remarked: “Cytoplasmic inheritance is a little bit like politics and religion from several aspects. First of all, you have to have faith in it. Second, one is called upon occasionally to give his opinion of cytoplasmic inheritance and to tell how he feels about the subject”. (P. 374 in Methodology in Basic Genetics, WJ Burdette, ed., Holden-Day, San Francisco, 1963.)