Reference Work Entry

Encyclopedia of Genetics, Genomics, Proteomics and Informatics

pp 952-952


ICE (interleukin-1β converting enzyme, caspase 1 in human chromosome 11q22)

A cysteine protease which is activated during Fas-mediated apoptosis. Its family includes CPP32 and Ich-1 proteases. The ICE is a mammalian homolog of ced-3. FAS, apoptosis, interleukins, CPP32, granzyme B, RNKP-1, IL-1, caspase; Druilhe A et al 2001 Cell Death Differ 8(6):649.

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