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Carcinogens and teratogens occur in the laboratory, industry, and agricultural environment. According to the estimates of the U.S. National Research Council, approximately 70,000 chemicals are in use and their number is increasing steadily. Their biological effects are not completely known. A survey of about 80 products of engineered protein did not appear toxic (with the exception of interferon) and one humanized antibody + linker might have had some genotoxicity (Mutation Res. 436:137). Many potentially mutagenic agents are present in every household, in the industry and in the research laboratories. The response to these potentially hazardous agents is determined or influenced by the genetic constitution of the individuals (susceptibility and resistance genes) and a number of factors in the environment besides the few agents named here. A very incomplete list follows:
Acetaldehyde: An intermediate of organic solvents, preservative of certain food products; it may be present in small...
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