Sirtuin (Sirt)

Reference work entry

NAD-dependent histone deacetylase and ADP ribosylase proteins of the Sir2 family. Sirtinol also activates many auxin-inducible plant genes. More than 65% of the 138 sirtinol-induced genes are auxin-inducible. Both auxin- and sirtinol-induction are apparently mediated by ubiquitin-activated protein degradation (Zhao Y et al 2003 Science 301:1107). Resveratrol may activate sirtuins and prolong life (Howitz K et al 2003 Nature [Lond] 425:191). Sirtuin mediates the mobilization of fat by repressing genes controlling the peroxisome proliferator-activator receptor-γ. Overproduction of Sirt reduces adipogenesis, and interference with Sirt RNA enhances fat production. SIRT4 functions in the mitochondria, represses glutamate dehydrogenase by AD2064-ribosylation, downregulates insulin secretion, and opposes the effect of caloric restriction in pancreatic β cells (Haigis MC et al 2006 Cell 126:941). SIRT1 and SIRT3 activate acetyl-CoE synthetase by deacetylation of the cytoplasmic or the...

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© Springer Science+Business Media 2008