Replication Bubble (replication eye)

Reference work entry
This is an indication of strand separation in a replicon (see Fig. R38). In an eukaryote nucleus an estimated 103 to 105 replication initiations occur during each cell cycle without any reinitiation per site, thus ensuring that the gene number is maintained. In yeast the dynamics of chromosome replication can be studied with the aid of DNA microarrays and it appears that the two ends of each chromosome replicate rather synchronously but the replication forks move differently in other regions. replication bidirectional, DNA replication, replication fork, replicon, promoter bubble, ORC, Replication Protein A, FFA, geminin; Diffley JFX 2001 Curr Biol 11:R367; Raghuraman MK et al 2001 Science 294:115.
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