Reference Work Entry

Encyclopedia of Public Health

pp 99-100

Case Cohort Study


In a case-cohort study, cases are defined as those participants of the cohort who developed the disease of interest, but controls are identified before the cases develop. This means that controls are randomly chosen from all cohort participants regardless of whether they have the disease of interest or not, and that baseline data can be collected early in the study.

Case-cohort studies are very similar to nested case-control studies. The main difference between a nested case-control study and a case-cohort study is the way in which controls are chosen. Generally, the main advantage of case-cohort design over nested case-control design is that the same control group can be used for comparison with different case groups in a case-cohort study. The main disadvantages of the case-cohort design is that it requires a more complicated statistical analysis and it can be less efficient than a nested case-control study under some circumstances ( ...

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