Ultrastructure of the Liver Sinusoid
The Liver Sinusoid
The liver sinusoids are the blood vessels that make up the microcirculation of the liver. Ultrastructure refers to the morphological cellular features that can be resolved by electron microscopy.
The liver has many immunological roles including production of acute-phase proteins, clearance of waste products generated by systemic inflammation and immune responses, deletion of activated T cells, and induction of tolerance to ingested and self-antigens (Parker and Picut 2012). The liver sinusoids form the interface between circulating blood and the hepatocytes thus are strategically placed to undertake and/or regulate the immune functions of the liver.
- Cogger VC, Le Couteur DG. Fenestrations in the liver sinusoidal endothelial cell. In: Arias I, Wolkoff A, Boyer J, Shafritz D, Fausto N, Alter H, Cohen A, editors. The liver: biology and pathobiology. Hokoben: Wiley; 2009. p. 387–404.Google Scholar
- Sørensen KK, McCourt P, Berg T, Crossley C, Le Couteur D, Wake K, et al. The scavenger endothelial cell – a new player in homeostasis and immunity. Am J Physiol. 2012;303:R1217.Google Scholar