Encyclopedia of Child Behavior and Development

2011 Edition
| Editors: Sam Goldstein, Jack A. Naglieri

Unipolar Depression

Reference work entry
DOI: https://doi.org/10.1007/978-0-387-79061-9_2990



Unipolar depression consists of one or more episodes of moderate to severe depression with persistent depressed mood and other symptoms of depression including suicidal ideation, suicide attempts, inability to experience pleasure when doing normally pleasurable activities, impaired concentration, change in appetite, change in weight, difficulty sleeping, and/or increased sleep. These major depressive episodes cannot be due to a medical condition, medication, abused substance, or Psychosis. If Manic, Mixed, or Hypomanic Episodes develop, the diagnosis is changed to Bipolar Disorder [1].



Unipolar Depression (and related suicide attempts) is a major cause of death worldwide. Prevalence varies widely, from 3% in Japan, 11% in Britain to 17% in the US. In most countries the number of people who would suffer from unipolar depression during their lives falls within an 8–12% range [8...

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  1. 1.
    American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, text revision: DSM-IV-TR (4th ed.). Washington, DC: American Psychiatric Publishing.CrossRefGoogle Scholar
  2. 2.
    Bair, M. J., Robinson, R. L., Katon, W., & Kroenke, K. (2003). Depression and pain comorbidity: A literature review. Archives of Internal Medicine, 163(20), 2433–2445.CrossRefPubMedGoogle Scholar
  3. 3.
    Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.CrossRefPubMedGoogle Scholar
  4. 4.
    Cutter, W. J., Norbury, R., & Murphy, D. G. (2003). Oestrogen, brain function, and neuropsychiatric disorders. Journal of Neurology, Neurosurgery and Psychiatry, 74(7), 837–840.CrossRefGoogle Scholar
  5. 5.
    Karasu, T. B., Gelenberg, A., Merriam, A., & Wang, P. (2000). Practice guideline for the treatment of patients with major depressive disorder (2nd ed., pp. 1–78). Arlington, VA: American Psychiatric Association.Google Scholar
  6. 6.
    Kendler, K. S. (2001). Twin studies of psychiatric illness. Archives of General Psychiatry, 58, 1005–1014.CrossRefPubMedGoogle Scholar
  7. 7.
    Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006). A Swedish national twin study of lifetime major depression. American Journal of Psychiatry, 163(1), 109–114.CrossRefPubMedGoogle Scholar
  8. 8.
    Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., et al. (2003). The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). Journal of the American Medical Association, 289(203), 3095–3105.CrossRefPubMedGoogle Scholar
  9. 9.
    Kessler, R. C., Berglund, P. A., Demler, O., Jin, R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Archives of General Psychiatry, 62(6), 593–602.CrossRefPubMedGoogle Scholar
  10. 10.
    Klein, J. (2008). Review: Cognitive behavioural therapy for adolescents with depression. Evidence-Based Mental Health, 11(3), 76.CrossRefGoogle Scholar
  11. 11.
    Posternak, M. A., & Miller, I. (2001). Untreated short-term course of major depression: A meta-analysis of outcomes from studies using wait-list control groups. Journal of Affective Disorders, 66(2–3), 139–146.CrossRefPubMedGoogle Scholar
  12. 12.
    Royal Pharmaceutical Society of Great Britain. (2008). British National Formulary (BNF 56). London: BMJ Group and RPS Publishing.Google Scholar
  13. 13.
    Ryan, R. D. (2005). Treatment of depression in children and adolescents. Lancet, 366(9489), 933–940.CrossRefPubMedGoogle Scholar
  14. 14.
    Trivedi, M. H., Fava, M., Wisniewski, S. R., Thase, M. E., Quitkin, F., Warden, D., et al. (2006). Medication augmentation after the failure of SSRIs for depression. New England Journal of Medicine, 354(12), 1243–1252.CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of NicosiaNicosiaCyprus