Paraneoplastic Syndromes in Pancreatic Cancer

  • Jens Werner
  • Stephan Herzig


Paraneoplastic Syndromes are defined as signs and symptoms that present distant to the site of the primary cancer or metastases. However, they are closely associated with the malignant disease and comprise metabolic, dystrophic and/or degenerative symptoms, which are consequences of humoral or hormonal factors. The clinical symptoms vary widely and include systemic and organ-specific manifestations. In some cases, these can become the major clinical problems determining survival. Systemic manifestations include frequent symptoms in pancreatic cancer patients, such as fever and cachexia. Organ-specific symptoms may represent as cutaneous, neurological, hematological, or endocrine symptoms. A special focus of this chapter is on diabetes mellitus associated with pancreatic tumors. The best-understood syndromes result from the tumor production of biologically active substances, or to a lesser extent, from autoimmune phenomena. Biological active agents may promote the growth of the tumor directly. In turn, growth-promoting agents of this type may become the focus of new approaches to anticancer treatment. After the successful treatment of the underlying malignant disease, paraneoplastic symptoms may resolve completely. Thus, an early recognition of paraneoplastic syndromes is very important in the management of patients with pancreatic cancer. In the following chapter, the most common paraneoplastic syndromes are described in detail.


Pancreatic Cancer Beta Cell Pancreatic Tumor Pancreatic Cancer Patient Paraneoplastic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jens Werner
    • 1
  • Stephan Herzig
    • 2
  1. 1.Department of General SurgeryUniversity of HeidelbergHeidelbergGermany
  2. 2.DKFZDivision of Molecular MetabolismHeidelbergGermany

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