Encyclopedia of Microfluidics and Nanofluidics

2008 Edition
| Editors: Dongqing Li

Lab-on-Chip Devices for Protein Analysis

  • Siddhartha Panda
  • Saiju Pyarajan
Reference work entry
DOI: https://doi.org/10.1007/978-0-387-48998-8_777
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Synonyms

Miniaturized systems; Chip-based systems; Proteomics; Protein chip; Protein profiling

Definition

Devices that have the capability of performing one or more analytical laboratory functions on a single platform of a small area (a few square millimeters to a few square centimeters) and are capable of handling extremely small fluid volumes (down to less than pico liters), which (among other applications) can be used for protein analysis.

Overview

Proteins are encoded by DNA and translated from RNA in the cell and are the effector molecules that play essential roles in carrying out cellular function. In disease state, various molecular changes occur in an individual at the DNA, RNA and protein level. Disease, therapy and drugs alter the structure, metabolism and functions of proteins. Understanding the expression and function of proteins in normal and pathophysiological conditions is critical for developing effective therapeutic strategies.

Protein analysis in general refers to...

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Siddhartha Panda
    • 1
  • Saiju Pyarajan
    • 2
  1. 1.Department of Chemical EngineeringIIT KanpurKanpurIndia
  2. 2.Department of Pathology and NYU Cancer InstituteNew York University School of MedicineNew YorkUSA