Encyclopedia of Microfluidics and Nanofluidics

2008 Edition
| Editors: Dongqing Li

Cell Culture (2D and 3D) on Chip

  • Jun Yang
  • Xiaolin Zheng
Reference work entry
DOI: https://doi.org/10.1007/978-0-387-48998-8_189


On-Chip Cell Culture; Cell Culture on a Chip


Cell culture on chip is defined as those methods to cultivate biological living cells on two- and three-dimensional (2D and 3D) chip devices. Microchip techniques can provide many advantages for cell culture systems because the scale of the cultivated environment inside the microchip is fitted to the size of the cells. The integration of microfabrication and cell culture technologies promises great advances in basic biological research, diagnostics, biosensors, high-throughput drug screening, and so on.


Cultivating cells in vitro is one of the cornerstones of modern biology. Cell culture is an essential tool in biological science and clinical analysis, with some applications such as drug screening and biosensors. Many advances have been made in developing automated high-throughput cell culture systems. However, high cost and large size limit their application. It is therefore highly desirable to produce...

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Jun Yang
    • 1
  • Xiaolin Zheng
    • 1
  1. 1.Bioengineering CollegeChongqing UniversityChongqingChina