Cellular Theory of Aging
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Cellular theories of aging propose that human aging is the result of cellular aging, whereby an increasing proportion of cells reach senescence, a terminal stage at which cells will cease to divide. This will limit the body's ability to regenerate and to respond to injury or stress. This process will occur over time in dividing cells; cell division gradually slows with each successive division, until a point of replicative senescence, at which point no further divisions will occur. The mechanism of replicative senescence is thought to involve some type of biological clock within the cell, which measures the number of cellular divisions and signals the cell to discontinue division at some genetically predetermined time.
The Cell Cycle and Cellular Senescence
The process of cell growth and division into two identical daughter cells occurs in a series of regulated steps called the cell cycle. There are four main stages that cells pass through during the cell cycle: (1) “G1” also called...
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