Encyclopedia of Aging and Public Health

2008 Edition
| Editors: Sana JD Loue, Martha Sajatovic

Cellular Theory of Aging

Reference work entry
DOI: https://doi.org/10.1007/978-0-387-33754-8_81

Cellular theories of aging propose that human aging is the result of cellular aging, whereby an increasing proportion of cells reach senescence, a terminal stage at which cells will cease to divide. This will limit the body's ability to regenerate and to respond to injury or stress. This process will occur over time in dividing cells; cell division gradually slows with each successive division, until a point of replicative senescence, at which point no further divisions will occur. The mechanism of replicative senescence is thought to involve some type of biological clock within the cell, which measures the number of cellular divisions and signals the cell to discontinue division at some genetically predetermined time.

The Cell Cycle and Cellular Senescence

The process of cell growth and division into two identical daughter cells occurs in a series of regulated steps called the cell cycle. There are four main stages that cells pass through during the cell cycle: (1) “G1” also called...

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Suggested Readings

  1. Crews DE (2003) Human senescence: evolutionary and biocultural perspectives. Cambridge University Press, New YorkGoogle Scholar
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  5. Masoro EJ (1999) Challenges of biological aging. Springer, New YorkGoogle Scholar
  6. Medina J (1996) The clock of ages: why we age—how we age—winding back the clock. Cambridge University Press, CambridgeGoogle Scholar
  7. Whitbourne SK (2001) Adult development and aging, biopsychosocial perspectives. Wiley, New YorkGoogle Scholar

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© Springer Science+Business Media, LLC 2008

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