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Neural Lipids in Parkinson's Disease

  • M. Barichella
  • G. Pezzoli
  • A. Mauri
  • C. Savardi
Reference work entry

Abstract:

A huge scientific effort is still ongoing in order to address the main etiologic and pathologic mechanisms responsible for the onset and the progression of Parkinson's Disease, one of the most common chronic progressive neurological disorders. The key role of oxidative damage in PD has been widely studied. Exposition to different toxic agents can promote oxidative damages, for instance, via inhibition of mitochondrial functions. This can lead to the formation of dangerous reactive radical compounds and of their relative oxidation products which have been frequently discovered to be present in elevated concentration in the Substantia Nigra pars compacta neurons of PD affected patients. In particular, being cellular membranes a preferential site for lipid oxidation, of increasing importance are also the studies investigating the contribution of membrane lipids composition to the aggregation of the α-Synuclein protein in filamentous amyloid-like fibrils, giving origin to insoluble intracellular inclusions with the capacity to cause neuronal damage. More recently, the role of the Cannabinoid-based compounds on the endocannabinoid receptors is under investigation due to the suggestions of a close interaction of the dopaminergic transmission with the endocannabinoid system which could ultimately behave as a compensatory mechanism in case the functionality of previous one is compromised. These compounds could thus be considered as a potential therapy to alleviate motor symptoms and L-dopa associated dyskinesias in PD affected patients.

Keywords

Substantia Nigra Parkinson Study Group Parkinsonian Brain Calcium Binding Protein Calbindin Binding Protein Calbindin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

αS

α-Synuclein

ATP

adenosine triphosphate

CB1

type 1 cannabinoid receptors

CB2

type 2 cannabinoid receptors

CNS

central nervous system

ETC

electron transport chain

GSH

glutathione

GSSG

glutathione disulfide

H2O2

hydrogen peroxide

HNE

4-hydroxynonenal

LB

Lewy bodies

LN

Lewy neurites

MAO

enzyme monoamine oxidase

MPP+

1-methyl-4-phenylpyridinium

MPTP

1-methyl-4-phenil-1,2,3,4-tetrahydropiridine

NO

nitric oxide

NOS

nitric oxide synthase

OH

hydroxyl free radical

PD

Parkinson's Disease

RNS

reactive nitrogen species

ROS

reactive oxygen species

Snca

human α-Synuclein gene

SNpc

substantia nigra pars compacta

SOD

superoxide dismutase

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • M. Barichella
  • G. Pezzoli
  • A. Mauri
  • C. Savardi

There are no affiliations available

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