Choline and Ethanolamine Glycerophospholipids

  • A. A. Farooqui
  • L. A. Horrocks
  • T. Farooqui
Reference work entry


Choline and ethanolamine glycerophospholipids are amphipathic molecules that are asymmetrically distributed in the bilayer. They provide the neural membranes with a suitable environment, fluidity, and ion permeability. The degree of saturation and the length of glycerophospholipid-acyl chains are important determinants of neural membrane properties. Choline and ethanolamine glycerophospholipids are synthesized at the endoplasmic reticulum and are transported to other membranous structures by phospholipid exchange and transfer proteins. Glycerophospholipids undergo base-exchange, methylation, and decarboxylation reactions for interconversion. These reactions and activities of phospholipases A2, C, and D are involved in the turnover, compositional maintenance, and rearrangements of glycerophospholipids in membranes. Glycerophospholipids are a storage depot for precursors for second messengers, and may be involved in membrane fusion, apoptosis, and regulation of the activities of membrane-bound enzymes and ion-channels.


Outer Leaflet Neural Membrane Glycerophospholipid Metabolism Ethanolamine Glycerophospholipids Choline Phosphotransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


arachidonic acid


cyclic adenosine monophosphate




cytidine triphosphate




docosahexaenoic acid


endoplasmic reticulum


free fatty acids


nuclear transcription factor κD


neuroprotectin D receptor


platelet-activating factor


protein kinase C






phosphatidic acid


phospholipase A


phospholipase C


phospholipase D


resolvin E receptor


resolvin D receptor


resolvin E receptor


tumor necrosis factor-α


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • A. A. Farooqui
  • L. A. Horrocks
  • T. Farooqui

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