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Choline and Ethanolamine Glycerophospholipids

  • A. A. Farooqui
  • L. A. Horrocks
  • T. Farooqui
Reference work entry

Abstract:

Choline and ethanolamine glycerophospholipids are amphipathic molecules that are asymmetrically distributed in the bilayer. They provide the neural membranes with a suitable environment, fluidity, and ion permeability. The degree of saturation and the length of glycerophospholipid-acyl chains are important determinants of neural membrane properties. Choline and ethanolamine glycerophospholipids are synthesized at the endoplasmic reticulum and are transported to other membranous structures by phospholipid exchange and transfer proteins. Glycerophospholipids undergo base-exchange, methylation, and decarboxylation reactions for interconversion. These reactions and activities of phospholipases A2, C, and D are involved in the turnover, compositional maintenance, and rearrangements of glycerophospholipids in membranes. Glycerophospholipids are a storage depot for precursors for second messengers, and may be involved in membrane fusion, apoptosis, and regulation of the activities of membrane-bound enzymes and ion-channels.

Keywords

Outer Leaflet Neural Membrane Glycerophospholipid Metabolism Ethanolamine Glycerophospholipids Choline Phosphotransferase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

AA

arachidonic acid

cAMP

cyclic adenosine monophosphate

CDP

cytidinediphospho

CTP

cytidine triphosphate

DAG

1,2-sn-diacylglycerols

DHA

docosahexaenoic acid

ER

endoplasmic reticulum

FFA

free fatty acids

NFκB

nuclear transcription factor κD

NPDR

neuroprotectin D receptor

PAF

platelet-activating factor

PKC

protein kinase C

PtdCho

phosphatidylcholine

PtdEtn

phosphatidylethanolamine

PtdH

phosphatidic acid

PLA

phospholipase A

PLC

phospholipase C

PLD

phospholipase D

RER1

resolvin E receptor

ResoDR1

resolvin D receptor

ResoER1

resolvin E receptor

TNF-α

tumor necrosis factor-α

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • A. A. Farooqui
  • L. A. Horrocks
  • T. Farooqui

There are no affiliations available

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