Bioactive Sphingolipids: An Overview on Ceramide, Ceramide 1-Phosphate Dihydroceramide, Sphingosine, Sphingosine 1-Phosphate

  • J. M. Kraveka
  • Y. A. Hannun
Reference work entry


Bioactive sphingolipids such as ceramide, ceramide 1-phosphate, dihydroceramide, sphingosine, and sphingosine 1-phosphate have key roles in cell proliferation, differentiation, senescence, apoptosis, migration, carcinogenesis, inflammation, and angiogenesis. There has been much progress made in understanding the complex pathways of sphingolipid metabolism and identifying the enzymes involved in sphingolipid production. This chapter reviews the structure, metabolism and functions of these bioactive sphingolipids.


Sphingosine Kinase Sphingolipid Metabolism Fatty Acid Chain Length Acid SMase Complex Sphingolipids 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:


alkaline sphingomyelinase


acid sphingomyelinase


ceramide 1-phoshpate






ceramide kinase


(dihydro)ceramide synthases




dihydroceramide desaturase




endoplasmic reticulum




glucosylceramide synthase

GluCer glucosylceramide; GSLs; glycosphingolipids; haCER

human alkaline ceramidase


human alkaline phytoceramidase


mitochondria-associated membranes


neutral sphingomyelinase


protein kinase C


retinoblastoma protein


sphingosine 1-phosphate


sphingosine kinases








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Authors and Affiliations

  • J. M. Kraveka
  • Y. A. Hannun

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