Glutamate and Cytokine-Mediated Alterations of Phospholipids in Head Injury and Spinal Cord Trauma

  • A. A. Farooqui
  • L. A. Horrocks
Reference work entry

Abstract:

Glutamate and cytokines play a major role in neurodegeneration and demyelination that occur following head injury and spinal cord trauma. Glutamate and cytokines produce their effect by stimulating glutamate and cytokine receptors and enhancing neural membrane phospholipid degradation through caspase-mediated activation of phospholipase A2. The stimulation of phospholipase A2 not only results in alteration in neural membrane composition and changes in neural membrane permeability and fluidity but also generates proinflammatory mediators, eicosanoids, and platelet activating factor, and oxidative stress mediators, isoprostanes, and 4-hydroxynonenal (4-HNE). The generation of these mediators along with the decrease in ATP and glutathione content, and generation of reactive oxygen species may contribute to neural cell death in head and spinal cord injury. Involvement of phospholipase A2 (PLA2) in neural cell injury suggests that phospholipase A2 inhibitors can limit neurodegeneration in head injury and spinal cord trauma and may therefore be used as potential drugs for the treatment of head and spinal cord injuries in animal models.

Keywords

Spinal Cord Arachidonic Acid Spinal Cord Injury Head Injury Docosahexaenoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations:

AACOCF3

arachidonoyl trifluoromethyl ketone

AMPA

α-amino-3-hydroxy-5-methyl-4-isoxazole propionate

BDNF

brain-derived neurotrophic factor

BEL

bromoenol lactone

CNQX

6-cyano-7-nitroquinoxaline-2,3-dione

COX-2

cyclooxygenase-2

4-HHE

4-hydroxyhexanal

4-HNE

4-hydroxynonenal

IFN

interferons

iNOS

inducible nitric oxide synthase

JNK

c-Jun amino-terminal kinase

KA

kainate

PLA2

phospholipases A2

NMDA

N-methyl-d-aspartate

PLC

phospholipase C

PlsEtn

plasmenylethanolamines

PtdCho

phosphatidylcholines

PtdEtn

phosphatidylethanolamines

PtdH

phosphatidic acids

PtdIns

phosphatidylinositols

PtdSer

phosphatidylserines

SPM

synaptosomal plasma membrane

TGF

tumor growth factors

TNF

tumor necrosis factors

Notes

Acknowledgments

We thank Siraj A Farooqui for providing figures and his help during preparation of this review.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • A. A. Farooqui
  • L. A. Horrocks

There are no affiliations available

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