Distance-Based Phylogeny Reconstruction (Fast-Converging)
Keywords and Synonyms
Learning an evolutionary tree
From a mathematical point of view, a phylogeny defines a probability space for random sequences observed at the leaves of a binary tree T. The tree T represents the unknown hierarchy of common ancestors to the sequences. It is assumed that (unobserved) ancestral sequences are associated with the inner nodes. The tree along with the associated sequences models the evolution of a molecular sequence, such as the protein sequence of a gene. In the conceptually simplest case, each tree node corresponds to a species, and the gene evolves within the organismal lineages by vertical descent.
Phylogeny reconstruction consists of finding Tfrom observed sequences. The possibility of such reconstruction is implied by fundamental principles of molecular evolution, namely, that random mutations within individuals at the genetic level spreading to an entire mating population are not uncommon, since often they...
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