Repair of DNA
Characteristics
The repair of DNA comprises a group of distinct biochemical pathways by which various types of damage to DNA, especially damage to the nitrogenous bases A, T, C and G, is repaired. Such damage can occur spontaneously in living cells as the result of the generation of products of oxidative metabolism that interact with the bases of DNA. Base damage in DNA also transpires as the result of interactions between environmental agents, especially cancer-causing chemicals, with DNA. DNA repair of base damage can be conveniently classified as follows:
- 1.
Reversal of Base Damage.This mode of DNA repair involves the direct reversal of selected types of base damage. A good example is the restoration of thymine dimers in DNA to their native monomeric state. Thymine dimers (T↔T) are formed by the abnormal chemical joining of adjacent thymine bases (T, T) in DNA and frequently occurs in cells that are exposed to ultraviolet (UV) radiation, such as sunlight. These lesions in DNA can...
References
- 1.Friedberg EC (1992) Cancer Answers: Encouraging Answers To 25 Questions You Were Always Afraid To Ask. W. H. Freeman & Co., New YorkGoogle Scholar
- 2.Friedberg EC, Walker GC, Siede W (1995) DNA Repair and Mutagenesis. ASM Press, Washington, DCGoogle Scholar
- 3.Friedberg EC (1985) Scientific American Reader: Cancer Biology. W. H. Freeman, New YorkGoogle Scholar