Proteomics
Eberhard Krause
Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany
ekrause@fmp-berlin.de
Synonyms
Proteome analysis; proteome research
Definition
The proteome has been defined as the entire protein complement expressed by a genome. Thus the field of proteomics involves the extensive study of the dynamic protein products of the genome and includes the identification, characterization and quantitation of proteins and their interactions.
Description
Genome and Proteome
The term proteome was introduced in 1995 (1) and has spread world wide within just a few years. Proteome is the linguistic equivalent of the term genome and describes the whole complement of proteins expressed by a cell at any given time. In contrast to the genome, the proteome is dynamic and very complex. The expression of a gene has no definitive relationship to the expression or abundance of its protein product. In addition, post-translational modifications...
References
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