Dermatology Therapy

2004 Edition
| Editors: N. Levine, C. C. Levine

Reactive perforating collagenosis

Reference work entry


Acquired perforating disease; collagenoma perforant verruciforme; acquired reactive perforating dermatosis


Inherited and acquired dermatosis in which the skin eliminates keratotic debris and altered collagen fibers by the transepidermal route


Minor skin trauma causes focal damage to collagen, followed by elimination of the disrupted collagen through the epidermis

Clinical manifestation

Flesh-colored, dome-shaped papules with a central keratotic plug occurring at sites of minor trauma; most commonly found on the extensor surfaces of the limbs and dorsa of the hands; linear distribution (Koebner phenomenon); scarring occurs with healing

Differential diagnosis

Kyrle's disease; perforating folliculitis; elastosis perforans serpiginosa; prurigo nodularis; Ferguson-Smith type of keratoacanthoma


Tretinoin 0.025% cream; adapalene 0.1% gel; photochemotherapy; isotretinoin; emollients to control pruritus


  1. Faver IR, Daoud MS, Su WP (1994) Acquired reactive perforating collagenosis. Report of six cases and review of the literature. Journal of the American Academy of Dermatology 30:575–580PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2004