Reference Work Entry

Rheumatology and Immunology Therapy

pp 731 -732

Prosorba column


Protein A immunoadsorption column.


The Prosorba column is the trade name for a staphylococcal protein A immunoadsorption column designed for use with plasmapheresis in the management of immune-mediated thrombocytopenia and rheumatoid arthritis.

Full Text

In the clinic setting, patients undergo plasmapheresis with separation of plasma and cells. The plasma is then run over the Prosorba column, which uses staphylococcal protein to remove immunoglobulin and immune complexes. The plasma and cells are then re-mixed and infused. Prosorba columns have been approved for use in immune-mediated thrombocytopenia and rheumatoid arthritis. Randomized controlled trials show that over 40% of subjects with refractory RA met ACR criteria for improvement after 12 weekly treatments with Prosorba column in comparison to 15% response in patients undergoing sham pheresis. Unfortunately central venous access lines were associated with significant adverse events and a ...

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