Necrotizing crescentic glomerulonephritis

Reference work entry


Crescentic glomerulonephritis is not a specific disease but rather a structural manifestation of severe glomerular inflammation that can be caused by different entities and pathogenic mechanisms. A crescent is defined as two or more layers of cells that are partially or completely filling Bowman's space. The term necrotizing crescentic glomerulonephritis refers to glomerulonephritis associated with crescent formation and the presence of glomerular necrosis. Crescentic glomerulonephritis often correlates with rapidly progressive glomerulonephritis, which is a clinical term designating glomerulonephritis accompanied by a rapid loss of renal function that can lead to end-stage renal failure within days to weeks.

Crescentic glomerulonephritis can be seen in three broad categories: anti-glomerular basement membrane (anti-GBM) antibody associated glomerulonephritis, immune complex mediated glomerulonephritis, and pauci-immune crescentic glomerulonephritis. Glomerular tuft necrosis...

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