Necrotizing crescentic glomerulonephritis

Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1953

Definition

Crescentic glomerulonephritis is not a specific disease but rather a structural manifestation of severe glomerular inflammation that can be caused by different entities and pathogenic mechanisms. A crescent is defined as two or more layers of cells that are partially or completely filling Bowman's space. The term necrotizing crescentic glomerulonephritis refers to glomerulonephritis associated with crescent formation and the presence of glomerular necrosis. Crescentic glomerulonephritis often correlates with rapidly progressive glomerulonephritis, which is a clinical term designating glomerulonephritis accompanied by a rapid loss of renal function that can lead to end-stage renal failure within days to weeks.

Crescentic glomerulonephritis can be seen in three broad categories: anti-glomerular basement membrane (anti-GBM) antibody associated glomerulonephritis, immune complex mediated glomerulonephritis, and pauci-immune crescentic glomerulonephritis. Glomerular tuft necrosis...

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References

  1. Jennette JC (1998) Crescentic glomerulonephritis. In: Jennette JC, Olson JL, Schwartz MM, Silva FG (eds) Hepinstall's pathology of the kidney. Lippincott-Raven, Philadelphia, pp 625–56Google Scholar
  2. Jennette JC, Falk RJ (1997) Diagnosis and management of glomerular diseases. Med Clin North Am 81:653–77PubMedCrossRefGoogle Scholar

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