Mixed chimerism
Reference work entry
DOI: https://doi.org/10.1007/3-540-29662-X_1855
Definition
Mutual exchange of cells and/or DNA between the organism of the donor and the host.
Full Text
Mixed chimerism frequently takes place when organs or cells are transplanted from one organism into the other resulting in mutual allogeneic persistence of "foreign" cells both in the organism of the host and in the transplant. Mixed chimerism can support the success of organ transplantation by facilitating transplantation tolerance.
References
- Brouha PC, Ildstat ST (2001) Mixed allogeneic chimerism. Past, present, and prospects for the future. Transplantation 72 (8 Suppl):S36–S42PubMedGoogle Scholar
- Sykes M, Sachs DH (2001) Mixed chimerism. Philos Trans R Soc Lond B Biol Sci 356:707–726PubMedGoogle Scholar
- Wekerle T (2001) Transplantation tolerance induced by mixed chimerism. J Heart Lung Transplant 20:816–823PubMedGoogle Scholar
Copyright information
© Springer-Verlag 2004