Definition
GFFKR domain refers to a conserved amino acid motif of the cytoplasmic tail of α integrin chains. It serves to stabilize the α and β integrin subunits in close spatial contact. This keeps the extracellular, ligand binding part of the integrin in a folded inactive form. Lysins, amino acids proximal to the GFFKR motif, are essential for interaction of the integrin α chain with RAPL. Binding of RAPL contributes to spatial separation of the cytoplasmic integrin chains, allowing unfolding of the extracellular part into a ligand binding integrin.
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© 2005 Springer-Verlag
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(2005). GFFKR Domain. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_7189
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DOI: https://doi.org/10.1007/3-540-29623-9_7189
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44244-8
Online ISBN: 978-3-540-29623-2
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