Definition
What is an inflammatory response? Inflammation is a general term for the local accumulation of fluid, plasma proteins and white blood cells that is initiated by physical injury, infection or a local immune response. More extensive tissue damage or infection may result in additional systemic reactions including fever and induction of certain genes mounting the acute phase response. These largely uniform responses of higher multicellular organisms to various injuries/infections are also known as the inflammatory response. The cells that invade tissues undergoing inflammatory responses are often called inflammatory cells or inflammatory infiltrates.
Acute inflammation is the term used to describe early and often transient episodes, while chronic inflammation occurs if the infection persists or during atherosclerosis or autoimmune responses. Many different forms of inflammation are seen in different diseases.
Characteristics
Innate Immunity and Inflammation
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References
Gaipl US, Brunner J, Beyer TD et al (2003) Disposal of Dying Cells: A Balancing Act Between Infection and Autoimmunity. Arthritis Rheum 48:6–11
Gershov D, Kim SJ, Brot N et al (2000) C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response: Implications for Systemic Autoimmunity. J Exp Med 192:1353–1363
Hack CE, Wolbink G-J, Schalkwijk C et al (1997) A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells. Immunol Today 18:111–115
Janeway CA Jr, Travers P (2001) Immunobiology: The Immune System in Health and Disease. Garland Publications, New York
Kracht M, Saklatvala J (2002) Transcriptional and post-transcriptional control of gene expression in inflammation. Cytokine 20:91–106
Volanakis JE (2001) Human C-reactive protein: expression, structure, and function. Mol Immunol 38:189–197
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© 2006 Springer-Verlag
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Sheriff, A., Herrmann, M., Voll, R.E., Gaipl, U.S., Kalden, J.R. (2006). Inflammatory Response. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-29623-9_4580
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DOI: https://doi.org/10.1007/3-540-29623-9_4580
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-44244-8
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