Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine

2006 Edition
| Editors: Detlev Ganten, Klaus Ruckpaul, Walter Birchmeier, Jörg T. Epplen, Klaus Genser, Manfred Gossen, Birgit Kersten, Hans Lehrach, Hartmut Oschkinat, Patrizia Ruiz, Peter Schmieder, Erich Wanker, Christiane Nolte

Nuclear Compartments

  • Alistair E. T. Newall
  • Jayson Wang
  • Denise SheerEmail author
Reference work entry
DOI: https://doi.org/10.1007/3-540-29623-9_2280

Definition

The genome of every eukaryotic cell is packaged within the cell nucleus. Conceptually, the role of the nucleus is to provide an environment suitable for both expression and maintenance of the genome. These two functions can be sub‐divided into a broad range of activities, including such diverse processes as transcription, RNA processing and export, DNA replication and DNA damage sensing and repair. In addition the genome must be tightly packaged, yet large parts of it nonetheless must be readily available as a transcriptional substrate either for basal metabolism or in response to specific stimuli.

The subdivision of biological processes into spatially and/or temporally discrete compartments confers numerous advantages. It permits the segregation of otherwise mutually exclusive processes, creates locally high concentrations of factors necessary for specific events/pathways and allows the coupling of energetically favourable and unfavourable reactions. Thus...

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Alistair E. T. Newall
    • 1
  • Jayson Wang
    • 1
  • Denise Sheer
    • 1
    Email author
  1. 1.Human Cytogenetics LaboratoryCancer Research UK London Research InstituteLondonUK