Lymphocyte Proliferation

  • René Crevel
Reference work entry
DOI: https://doi.org/10.1007/3-540-27806-0_920

Synonyms

lymphocyte transformation, lymphocyte mitogenesis, lymphocyte proliferative response

Definition

Lymphocyte proliferation is defined as the process whereby lymphocytes begin to synthesize DNA after cross-linking of their antigen receptor either following recognition of antigen or stimulation by a polyclonal activator (mitogen).

Characteristics.

Events in lymphocyte proliferation

Lymphocyte proliferation is a fundamental characteristic of the response of lymphocytes to antigenic stimulation. In physiological situations, contact between a lymphocyte and an antigen-presenting cell (APC) results in the formation of an immunological synapse. In this synapse, binding to the 3 T cell receptor (TCR) of the peptide-MHC complex carried by antigen-presenting cells, together with a costimulatory signal delivered by interaction between 3  CD28and its ligand, initiates proliferation, while the synapse itself is stabilized by interactions between adhesion molecules and their ligands on the...
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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • René Crevel
    • 1
  1. 1.Safety & Environmental Assurance CentreUnilever ColworthSharnbrook, BedfordUK