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The Genera Proteus, Providencia, and Morganella

  • Jim Manos
  • Robert Belas

Introduction

The three genera Proteus, Morganella and Providencia presently comprise a total of ten species. All are motile, Gram-negative rods with peritrichous flagella, and are assigned to the Enterobacteriaceae family mainly on the basis of shared biochemical characteristics. Most significantly, they are characterized by their ability to oxidatively deaminate phenylalanine and, in most cases (except for some Providencia spp.), to hydrolyze urea (Farmer et al., 1977; Moltke, 1927; Wenner and Retger, 1919). Unusual features include the ability of Proteus sp. to differentiate into swarmer cells upon colonization of solid surfaces. This topic will be covered in more detail in ensuing sections.

Interest in the species comprising these genera has occurred mainly from a clinical perspective, as they include a number of significant human pathogens. In human disease, most infections are associated with prolonged hospitalization and in the case of Proteus and Morganellaspp., colonization...

Keywords

Virulence Factor Uroepithelial Cell Swarmer Cell zapA Expression Peritrichous Flagellum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Literature Cited

  1. Adegbola, R. A., D. C. Old, and B. W. Senior. 1983 The adhesins and fimbriae of Proteus mirabilis strains associated with high and low affinity for the urinary tract J. Med. Microbiol. 16 427–431PubMedGoogle Scholar
  2. Ahren, C. M., M. Jertborn, L. Herclik, B. Kaijser, and A. M. Svennerholm. 1990 Infection with bacterial enteropathogens in Swedish travellers to South-East Asia—a prospective study Epidemiol. Infect. 105 325–333PubMedGoogle Scholar
  3. Akopyanz, N., N. O. Bukanov, T. U. Westblom, S. Kresovich, and D. E. Berg. 1992 DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting Nucl. Acids Res. 20 5137–5142PubMedGoogle Scholar
  4. Albert, M. J., K. Alam, M. Ansaruzzaman, M. M. Islam, A. S. Rahman, K. Haider, N. A. Bhuiyan, S. Nahar, N. Ryan, J. Montanaro, and M. M. Mathan. 1992 Pathogenesis of Providencia alcalifaciens-induced diarrhea Infect. Immun. 60 5017–5024PubMedGoogle Scholar
  5. Albert, M. J., A. S. Faruque, and D. Mahalanabis. 1998 Association of Providencia alcalifaciens with diarrhea in children J. Clin. Microbiol. 36 1433–1435PubMedGoogle Scholar
  6. Alberti, L., and R. M. Harshey. 1990 Differentiation of Serratia marcescens 274 into swimmer and swarmer cells J. Bacteriol. 172 4322–4328PubMedGoogle Scholar
  7. Al-Jumaili, I. J., and G. A. Fenwick. 1978 Bacteriocine typing of Providencia isolates Zentralbl. Bakteriol. [Orig A] 240 202–207Google Scholar
  8. Allison, C., and C. Hughes. 1991 Bacterial swarming: An example of prokaryotic differentiation and multicellular behaviour Sci. Prog. 75 403–422PubMedGoogle Scholar
  9. Allison, C., N. Coleman, P. L. Jones, and C. Hughes. 1992 Ability of Proteus mirabilis to invade human urothelial cells is coupled to motility and swarming differentiation Infect. Immun. 60 4740–4746PubMedGoogle Scholar
  10. Allison, C., H. C. Lai, D. Gygi, and C. Hughes. 1993 Cell differentiation of Proteus mirabilis is initiated by glutamine, a specific chemoattractant for swarming cells Molec. Microbiol. 8 53–60Google Scholar
  11. Allison, C., L. Emody, N. Coleman, and C. Hughes. 1994 The role of swarm cell differentiation and multicellular migration in the uropathogenicity of Proteus mirabilis J. Infect. Dis. 169 1155–1158PubMedGoogle Scholar
  12. Anderson, R. L., and F. B. Engley. 1978 Typing methods for Proteus rettgeri: Comparison of biotype, antibiograms, serotype, and bacteriocin production J. Clin. Microbiol. 8 715–724PubMedGoogle Scholar
  13. Andrighetto, C., P. De Dea, A. Lombardi, E. Neviani, L. Rossetti, and G. Giraffa. 1998 Molecular identification and cluster analysis of homofermentative thermophilic lactobacilli isolated from dairy products Res. Microbiol. 149 631–643PubMedGoogle Scholar
  14. Armitage, J. P., R. J. Rowbury, and D. G. Smith. 1974 The effects of chloramphenicol, nalidixic acid and penicillin on the growth and division of swarming cells of Proteus mirabilis J. Med. Microbiol. 7 459–464PubMedGoogle Scholar
  15. Armitage, J. P., and D. G. Smith. 1978 Flagella development during swarmer differentiation in Proteus mirabilis FEMS Microbiol. Lett. 4 163–165Google Scholar
  16. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. A. Smith, J. G. Seidman, and K. Struhl. 1987 Escherichia coli, Plasmids and Bacteriophages Current Protocols in Molecular Biology Greene Publishing and John Wiley & Sons New York NY 112Google Scholar
  17. Bagel, J., and M. E. Grossman. 1985 Hemorrhagic bullae associated with Morganella morganii septicemia J. Am. Acad. Dermatol. 12 575–576PubMedGoogle Scholar
  18. Bahrani, F. K., S. Cook, R. A. Hull, G. Massad, and H. L. Mobley. 1993a Proteus mirabilis fimbriae: N-terminal amino acid sequence of a major fimbrial subunit and nucleotide sequences of the genes from two strains Infect. Immun. 61 884–891PubMedGoogle Scholar
  19. Bahrani, F. K., G. Massad, and H. L. T. Mobley. 1993b Isolation, N-terminal analysis and expression of a 24 KDa fimbrial protein of uropathogenic Proteus mirabilis In: Domer, J. E., Hall, N. K., Eisenstein, B. I., Maloney, P., Fung, D. Y. C. and Holmes, K. V. 93rd General meeting of the American Society of Microbiology, Atlanta, GA The American Society for Microbiology Washington DC B–167Google Scholar
  20. Bahrani, F. K., G. Massad, C. V. Lockatell, D. E. Johnson, R. G. Russell, J. W. Warren, and H. L. Mobley. 1994 Construction of an MR/P fimbrial mutant of Proteus mirabilis: Role in virulence in a mouse model of ascending urinary tract infection Infect. Immun. 62 3363–3371PubMedGoogle Scholar
  21. Bale, M. J., S. M. McLaws, and J. M. Matsen. 1985 The spot indole test for identification of swarming Proteus Am. J. Clin. Pathol. 83 87–90PubMedGoogle Scholar
  22. Barragan Casas, J. M., J. M. Hernandez Hernandez, M. A. Garcinuno Jimenez, M. A. Gonzalo Molina, P. Carbonero Diaz, R. Ibanez, and R. Serrano-Herranz. 1999 Bacteremia caused by digestive system endoscopy Rev. Esp. Enferm. Dig. 91 105–116PubMedGoogle Scholar
  23. Bassler, B. L., M. Wright, and M. R. Silverman. 1994 Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: Sequence and function of genes encoding a second sensory pathway Molec. Microbiol. 13 273–286Google Scholar
  24. Bauernfeind, A., and G. Wiersma. 1977 Nosocomial infections of the urinary tract by Proteus rettgeri Immun. Infekt. 5 138–141PubMedGoogle Scholar
  25. Belas, R., M. Simon, and M. Silverman. 1986 Regulation of lateral flagella gene transcription in Vibrio parahaemolyticus J. Bacteriol. 167 210–218PubMedGoogle Scholar
  26. Belas, R., D. Erskine, and D. Flaherty. 1991 Proteus mirabilis mutants defective in swarmer cell differentiation and multicellular behavior J. Bacteriol. 173 6279–6288PubMedGoogle Scholar
  27. Belas, R., D. Erskine, and D. Flaherty. 1991 Transposon mutagenesis in Proteus mirabilis J. Bacteriol. 173 6289–6333PubMedGoogle Scholar
  28. Belas, R. 1992 The swarming phenomenon of Proteus mirabilis Am. Soc. Microbiol. News 58 15–22Google Scholar
  29. Belas, R. 1994a Expression of multiple flagellin-encoding genes of Proteus mirabilis J. Bacteriol. 176 7169–81PubMedGoogle Scholar
  30. Belas, R., and D. Flaherty. 1994b Sequence and genetic analysis of multiple flagellin-encoding genes from Proteus mirabilis Gene 148 33–41PubMedGoogle Scholar
  31. Belas, R., M. Goldman, and K. Ashliman. 1995 Genetic analysis of Proteus mirabilis mutants defective in swarmer cell elongation J. Bacteriol. 177 823–828PubMedGoogle Scholar
  32. Belas, R., R. Schneider, and M. Melch. 1998 Characterization of Proteus mirabilis precocious swarming mutants: Identification of rsbA, encoding a regulator of swarming behavior J. Bacteriol. 180 6126–6139PubMedGoogle Scholar
  33. Bisset, K. A. 1973a The motion of the swarm in Proteus mirabilis J. Med. Microbiol. 6 33–35PubMedGoogle Scholar
  34. Bisset, K. A. 1973b The zonation phenomenon and structure of the swarm colony in Proteus mirabilis J. Med. Microbiol. 6 429–433PubMedGoogle Scholar
  35. Bisset, K. A., and C. W. Douglas. 1976 A continuous study of morphological phase in the swarm of Proteus J. Med. Microbiol. 9 229–231PubMedGoogle Scholar
  36. Braun, V., and T. Focareta. 1991 Pore-forming bacterial protein hemolysins (cytolysins) Crit. Rev. Microbiol. 18 115–158PubMedGoogle Scholar
  37. Braun, V., R. Schonherr, and S. Hobbie. 1993 Enterobacterial hemolysins: Activation, secretion and pore formation Trends Microbiol. 1 211–6PubMedGoogle Scholar
  38. Braunstein, H., and M. Tomasulo. 1978 Identification of Proteus morganii and distinction from other Proteus species Am. J. Clin. Pathol. 70 905–908PubMedGoogle Scholar
  39. Brenner, D. J., J. J. Farmer III, G. R. Fanning, A. G. Steigerwalt, P. Klykken, H. G. Wathen, F. W. Hickman, and W. H. Ewing. 1978 Deoxyribonucleic acid relatedness of Proteus and Providencia species Int. J. Syst. Bacteriol. 28 269–282Google Scholar
  40. Brogan, T. D., J. Nettleton, and C. Reid. 1971 The swarming of Proteus on semisynthetic media J. Med. Microbiol. 4 1–11PubMedGoogle Scholar
  41. Cipriani, S., F. Pannelli, A. R. Picciola, and T. Rocchi. 1988 Urine bacterial flora and chemoantibiotic resistance: observations on ambulatory patients and hospitalized patients at the local health district No. 11 of Fabriano (Ancona) Quaderni Sclavo di Diagnostica clinica e di laboratorio 24 225–237PubMedGoogle Scholar
  42. Coetzee, J. N. 1967 Bacteriocinogeny in strains of Providence and Proteus morganii Nature 213 614–616PubMedGoogle Scholar
  43. Cohen, T. D., and G. M. Preminger. 1996 Struvite calculi Semin. Nephrol. 16 425–434PubMedGoogle Scholar
  44. Cornelis, G., M. Van Bouchaute, and G. Wauters. 1981 Plasmid-encoded lysine decarboxylation in Proteus morganii J. Clin. Microbiol. 14 365–369PubMedGoogle Scholar
  45. Cosenza, B. J., and J. D. Podgwaite. 1966 A new species of Proteus isolated from larvae of the gypsy moth Porthetria dispar (L.) Ant. v. Leeuwenhoek 32 187–191Google Scholar
  46. Costas, M., B. Holmes, and L. L. Sloss. 1987 Numerical analysis of electrophoretic protein patterns of Providencia rustigianii strains from human diarrhoea and other sources J. Appl. Bacteriol. 63 319–328PubMedGoogle Scholar
  47. Costas, M., B. Holmes, K. A. Frith, C. Riddle, and P. M. Hawkey. 1993 Identification and typing of Proteus penneri and Proteus vulgaris biogroups 2 and 3, from clinical sources, by computerized analysis of electrophoretic protein patterns J. Appl. Bacteriol. 75 489–498PubMedGoogle Scholar
  48. Das, A. S., D. N. Mazumder, D. Pal, and U. K. Chattopadhyay. 1996 A study of nosocomial diarrhea in Calcutta, IN J. Gastroenterol. 15 12–13Google Scholar
  49. Davis, J. A., and R. E. Banks. 1991 Modification to the RITARD surgical model J. Invest. Surg. 4 499–504PubMedGoogle Scholar
  50. Dienes, L. 1946 Reproductive processes in Proteus cultures Proc. Soc. Exp. Biol. Med. 63 265–270Google Scholar
  51. Dijkshoorn, L., B. Van Harsselaar, I. Tjernberg, P. J. Bouvet, and M. Vaneechoutte. 1998 Evaluation of amplified ribosomal DNA restriction analysis for identification of Acinetobacter genomic species Syst. Appl. Microbiol. 21 33–39PubMedGoogle Scholar
  52. Douglas, C. W., and K. A. Bisset. 1976 Development of concentric zones in the Proteus swarm colony J. Med. Microbiol. 9 497–500PubMedGoogle Scholar
  53. Douglas, C. W. 1979 Measurement of Proteus cell motility during swarming J. Med. Microbiol. 12 195–199PubMedGoogle Scholar
  54. du Toit, P. J., C. H. van Aswegen, J. A. Nel, P. L. Steyn, A. J. Ligthelm, and D. J. du Plessis. 1995 In vivo effects of urease-producing bacteria involved with the pathogenesis of infection-induced urolithiasis on renal urokinase and sialidase activity Urol. Res. 23 335–338PubMedGoogle Scholar
  55. Eberhard, A. 1972 Inhibition and activation of bacterial luciferase synthesis J. Bacteriol. 109 1101–1105PubMedGoogle Scholar
  56. Eberhard, A., A. L. Burlingame, C. Eberhard, G. L. Kenyon, K. H. Nealson, and N. J. Oppenheimer. 1981 Structural identification of autoinducer of Photobacterium fischeri luciferase Biochemistry 20 2444–2449PubMedGoogle Scholar
  57. Eberl, L., M. K. Winson, C. Sternberg, G. S. Stewart, G. Christiansen, S. R. Chhabra, B. Bycroft, P. Williams, S. Molin, and M. Givskov. 1996 Involvement of N-acyl-L-hormoserine lactone autoinducers in controlling the multicellular behaviour of Serratia liquefaciens Molec. Microbiol. 20 127–136Google Scholar
  58. Eberl, L., S. Molin, and M. Givskov. 1999 Surface motility of Serratia liquefaciens MG1 J. Bacteriol. 181 1703–1712PubMedGoogle Scholar
  59. Emody, L., T. Pal, N. V. Safonova, B. Kuch, and N. K. Golutva. 1980 Alpha-Haemolysin: An additive virulence factor in Escherichia coli Acta Microbiol. Acad. Sci. Hung. 27 333–342PubMedGoogle Scholar
  60. Ewing, W. H., B. R. Davis, and J. V. Sikes. 1972 Biochemical characterization of Providencia Pub. Health Lab. 30 25–38Google Scholar
  61. Farmer, J. J., F. W. Hickman, D. J. Brenner, M. Schreiber, and D. G. Rickenbach. 1977 Unusual Enterobacteriaceae: “Proteus rettgeri”, that “change” into Providencia stuartii J. Clin. Microbiol. 6 373–378PubMedGoogle Scholar
  62. Fletcher, M., S. R. Oppenheimer, and J. W. Warren. 1994 Colonization of urinary catheters by Escherichia coli and Providencia stuartii in a laboratory model system J. Urol. 152 232–236PubMedGoogle Scholar
  63. Freeman, J. A., and B. L. Bassler. 1999 A genetic analysis of the function of LuxO, a two-component response regulator involved in quorum sensing in Vibrio harveyi Molec. Microbiol. 31 665–677Google Scholar
  64. Gabrilovich, I. M., M. V. Zarochentsev, and S. R. Saimov. 1998 Comparative study of Morganella and Providencia bacteriophages Zh. Mikrobiol. Epidemiol. Immunobiol. 5 20–22PubMedGoogle Scholar
  65. Gilbert, D. G. 1989 Phylodendron, Version 0.8 Biology Department, Indiana University Bloomington INGoogle Scholar
  66. Givskov, M., J. Ostling, L. Eberl, P. W. Lindum, A. B. Christensen, G. Christiansen, S. Molin, and S. Kjelleberg. 1998 Two separate regulatory systems participate in control of swarming motility of Serratia liquefaciens MG1 J. Bacteriol. 180 742–745PubMedGoogle Scholar
  67. Gmeiner, J., H. Mayer, I. Fromme, K. Kotelko, and K. Zych. 1977 Ribitol-containing lipopolysaccharides from Proteus mirabilis and their serological relationship Eur. J. Biochem. 72 35–40PubMedGoogle Scholar
  68. Goebel, W., T. Chakraborty, and J. Kreft. 1988 Bacterial hemolysins as virulence factors Ant. v. Leeuwenhoek 54 453–463Google Scholar
  69. Gomez-Duarte, O. G., B. Lucas, Z. X. Yan, K. Panthel, R. Haas, and T. F. Meyer. 1998 Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B Vaccine 16 460–471PubMedGoogle Scholar
  70. Gomez-Lus, R., M. C. Rubio Calvo, and L. L. Mur. 1977 Aminoglycoside inactivating enzymes produced by R plasmids of Escherichia coli, Citrobacter freundii, Klebsiella pneumoniae, Proteus vulgaris, Providencia stuartii and Serratia marcescens J. Antimicrob. Chemother. 3(Suppl. C) 39–41PubMedGoogle Scholar
  71. Guentzel, M. N. 1991 Escherichia, Klebsiella, Enterobacter, Serratia, Citrobacter and Proteus In: S. Baron (Ed.) Medical Microbiology, 3rd ed Churchill Livingstone New York NY 377–387Google Scholar
  72. Gunalp, A. 1979 The role of enteric bacteria in childhood urinary tract infections and their in vitro response to antimicrobial agents Mikrobiyol. Bul. 13 13–25PubMedGoogle Scholar
  73. Guth, B. E., and E. Perrella. 1996 Prevalence of invasive ability and other virulence-associated characteristics in Providencia alcalifaciens strains isolated in Sao Paulo, Brazil J. Med. Microbiol. 45 459–462PubMedGoogle Scholar
  74. Guth, B. E., K. Irino, and L. R. Trabulsi. 1999 Clonal structure of Providencia alcalifaciens strains isolated from diarrhoeal stools in Sao Paulo, Brazil J. Med. Microbiol. 48 205–209PubMedGoogle Scholar
  75. Guthrie, L. A., L. C. McPhail, P. M. Henson, and R. B. Johnston Jr. 1984 Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme J. Exp. Med. 160 1656–1671PubMedGoogle Scholar
  76. Gygi, D., M. M. Rahman, H. C. Lai, R. Carlson, J. Guard-Petter, and C. Hughes. 1995 A cell-surface polysaccharide that facilitates rapid population migration by differentiated swarm cells of Proteus mirabilis Molec. Microbiol. 17 1167–1175Google Scholar
  77. Hacker, J., C. Hughes, H. Hof, and W. Goebel. 1983 Cloned hemolysin genes from Escherichia coli that cause urinary tract infection determine different levels of toxicity in mice Infect. Immun. 42 57–63PubMedGoogle Scholar
  78. Hamilton, T. A., and D. O. Adams. 1987 Molecular mechanisms of signal transduction in macrophages Immunol. Today 8 151–158Google Scholar
  79. Harshey, R., and T. Matsuyama. 1994 Dimorphic transition in E. coli and S. typhimurium: Surface-induced differentiation into hyperflagellate swarmer cells Proc. Natl. Acad. Sci. USA 91 8631–8635PubMedGoogle Scholar
  80. Hawkey, P. M., J. L. Penner, M. R. Potten, M. Stephens, L. J. Barton, and D. C. Speller. 1982a Prospective survey of fecal, urinary tract, and environmental colonization by Providencia stuartii in two geriatric wards J. Clin. Microbiol. 16 422–426PubMedGoogle Scholar
  81. Hawkey, P. M., M. R. Potten, and M. Stephens. 1982b The use of pre-enrichment for the isolation of small numbers of gentamicin-resistant Providencia stuartii from faeces J. Hosp. Infect. 3 369–374PubMedGoogle Scholar
  82. Hawkey, P. M., A. McCormick, and R. A. Simpson. 1986a Selective and differential medium for the primary isolation of members of the Proteeae J. Clin. Microbiol. 23 600–603PubMedGoogle Scholar
  83. Hawkey, P. M., J. L. Penner, A. H. Linton, C. A. Hawkey, L. J. Crisp, and M. Hinton. 1986b Speciation, serotyping, antimicrobial sensitivity and plasmid content of Proteeae from the environment of calf-rearing units in South West England J. Hyg. (London) 97 405–417Google Scholar
  84. Haynes, J., and P. M. Hawkey. 1989 Providencia alcalifaciens and travellers’ diarrhoea Brit. Med. J. 299 94–95PubMedGoogle Scholar
  85. Heard, D. J., E. R. Jacobson, R. E. Clemmons, and G. A. Campbell. 1988 Bacteremia and septic arthritis in a West African dwarf crocodile J. Am. Vet. Med. Assoc. 192 1453–1454PubMedGoogle Scholar
  86. Henriksen, S. D. 1950 A comparison of the phenylpyruvic acid reaction and the urease testin the differentiation of Proteus from other enteric organisms J. Bacteriol. 60 225–231PubMedGoogle Scholar
  87. Hickman, F. W., and J. J. I. Farmer. 1976 Differentiation of Proteus mirabilis by bacteriophage typing and the Dienes reaction J. Clin. Microbiol. 10 1–9Google Scholar
  88. Hickman, F. W., J. J. d. Framer, A. G. Steigerwalt, and D. J. Brenner. 1980 Unusual groups of Morganella (“Proteus”) morganii isolated from clinical specimens: Lysine-positive and ornithine-negative biogroups J. Clin. Microbiol. 12 88–94PubMedGoogle Scholar
  89. Hickman, F. W., A. G. Steigerwalt, J. J. D. Farmer, and D. J. Brenner. 1982 Identification of Proteus penneri sp. nov., formerly known as Proteus vulgaris indole negative or as Proteus vulgaris biogroup 1 J. Clin. Microbiol. 15 1097–1102PubMedGoogle Scholar
  90. Hickman-Brenner, F. W., J. J. d. Farmer, A. G. Steigerwalt, and D. J. Brenner. 1983 Providencia rustigianii: A new species in the family Enterobacteriaceae formerly known as Providencia alcalifaciens biogroup 3 J. Clin. Microbiol. 17 1057–1060PubMedGoogle Scholar
  91. Higashitani, A., N. Higashitani, and K. Horiuchi. 1995 A cell division inhibitor SulA of Escherichia coli directly interacts with FtsZ through GTP hydrolysis Biochem. Biophys. Res. Commun. 209 198–204PubMedGoogle Scholar
  92. Hoeniger, J. F. M. 1964 Cellular changes accompanying the swarming of Proteus mirabilis. I: Observations on living cultures Can. J. Microbiol. 10 1–9PubMedGoogle Scholar
  93. Hoeniger, J. F. M. 1965 Development of flagella by Proteus mirabilis J. Gen. Microbiol. 40 29–42Google Scholar
  94. Hoeniger, J. F. M. 1966 Cellular changes accompanying the swarming of Proteus mirabilis. II: Observations of stained organisms Can. J. Microbiol. 12 113–122PubMedGoogle Scholar
  95. Hoeniger, J. F. M., and E. A. Cinits. 1969 Cell wall growth during differentiation of Proteus swarmers J. Bacteriol. 148 736–738Google Scholar
  96. Hoffmann, G., G. Gajdos, M. Czako, M. Kerenyi, V. Toth, L. Emody, and T. Tomcsanyi. 1997 Genetic diversity in Proteus penneri Acta Biol. Hung. 48 395–398PubMedGoogle Scholar
  97. Hoffmann, G., G. Gajdos, M. Czako, M. Kerenyi, V. Toth, L. Emody, and T. Tomcsanyi. 1998 Diversity among clinical isolates of Proteus penneri detected by random amplified polymorphic DNA analysis Zentralbl. Bakteriol. 288 351–360PubMedGoogle Scholar
  98. Houang, E. T., P. C. Tam, S. L. Lui, and A. F. Cheng. 1999 The use of CHROMagar Orientation as a primary isolation medium with presumptive identification for the routine screening of urine specimens Acta Pathologica Microbiologica et Immunologica Scandinavica 107 859–862Google Scholar
  99. Houwink, A. L., and W. van Iterson. 1950 Electron microscopical observations on bacterial cytology. II: A study of flagellation Biochim. Biophys. Acta 5 10–16PubMedGoogle Scholar
  100. Huisman, O., and R. D’Ari. 1981 An inducible DNA replication-cell division coupling mechanism in E. coli Nature 290 797–799PubMedGoogle Scholar
  101. Huisman, O., R. D’Ari, and S. Gottesman. 1984 Cell-division control in Escherichia coli: specific induction of the SOS function SfiA protein is sufficient to block septation Proc. Natl. Acad. Sci. USA 81 4490–4494PubMedGoogle Scholar
  102. Janda, J. M., S. L. Abbott, S. Khashe, and T. Robin. 1996 Biochemical investigations of biogroups and subspecies of Morganella morganii J. Clin. Microbiol. 34 108–113PubMedGoogle Scholar
  103. Janda, J. M., S. L. Abbott, D. Woodward, and S. Khashe. 1998 Invasion of HEp-2 and other eukaryotic cell lines by Providenciae: Further evidence supporting the role of Providencia alcalifaciens in bacterial gastroenteritis Curr. Microbiol. 37 159–165PubMedGoogle Scholar
  104. Jensen, K. T., W. Frederiksen, F. W. Hickman-Brenner, A. G. Steigerwalt, C. F. Riddle, and D. J. Brenner. 1992 Recognition of Morganella subspecies, with proposal of Morganella morganii subsp. morganii subsp. nov. and Morganella morganii subsp. sibonii subsp. nov Int. J. Syst. Bacteriol. 42 613–620PubMedGoogle Scholar
  105. Johnson, D. E., R. G. Russell, C. V. Lockatell, J. C. Zulty, J. W. Warren, and H. L. Mobley. 1993 Contribution of Proteus mirabilis urease to persistence, urolithiasis, and acute pyelonephritis in a mouse model of ascending urinary tract infection Infect. Immun. 61 2748–2754PubMedGoogle Scholar
  106. Jones, B. D., and H. L. Mobley. 1987 Genetic and biochemical diversity of ureases of Proteus, Providencia, and Morganella species isolated from urinary tract infection Infect. Immun. 55 2198–2203PubMedGoogle Scholar
  107. Jones, B. D., C. V. Lockatell, D. E. Johnson, J. W. Warren, and H. L. Mobley. 1990 Construction of a urease-negative mutant of Proteus mirabilis: Analysis of virulence in a mouse model of ascending urinary tract infection Infect. Immun. 58 1120–1123PubMedGoogle Scholar
  108. Kaplan, H. B., and E. P. Greenberg. 1985 Diffusion of autoinducer is involved in regulation of the Vibrio fischeri luminescence system J. Bacteriol. 163 1210–1214PubMedGoogle Scholar
  109. Karch, H., and K. Nixdorff. 1981 Antibody-producing cell responses to an isolated outer membrane protein and to complexes of this antigen with lipopolysaccharide or with vesicles of phospholipids from Proteus mirabilis Infect. Immun. 31 862–867PubMedGoogle Scholar
  110. Karch, H., and K. Nixdorff. 1983 Modulation of the IgG subclass responses to lipopolysaccharide by bacterial membrane components: Differential adjuvant effects produced by primary and secondary stimulation J. Immunol. 131 6–8PubMedGoogle Scholar
  111. Keren, G., and D. L. Tyrrel. 1987 Gram-negative septicemia caused by Providencia stuartii Int. J. Pediatr. Nephrol. 8 91–94PubMedGoogle Scholar
  112. Kilian, M., B. Thomsen, T. E. Petersen, and H. S. Bleeg. 1983 Occurrence and nature of bacterial IgA proteases Ann. NY Acad. Sci. 409 612–624PubMedGoogle Scholar
  113. Kitch, T. T., M. R. Jacobs, and P. C. Appelbaum. 1994 Evaluation of RapID onE system for identification of 379 strains in the family Enterobacteriaceae and oxidase-negative, gram-negative nonfermenters J. Clin. Microbiol. 32 931–934PubMedGoogle Scholar
  114. Koronakis, V., M. Cross, B. Senior, E. Koronakis, and C. Hughes. 1987 The secreted hemolysins of Proteus mirabilis, Proteus vulgaris, and Morganella morganii are genetically related to each other and to the alpha-hemolysin of Escherichia coli J. Bacteriol. 169 1509–1515PubMedGoogle Scholar
  115. Koronakis, V., and C. Hughes. 1988a Identification of the promoters directing in vivo expression of hemolysin genes in Proteus vulgaris and Escherichia coli Molec. Gen. Genet. 213 99–104PubMedGoogle Scholar
  116. Koronakis, V., E. Koronakis, and C. Hughes. 1988b Comparison of the haemolysin secretion protein HlyB from Proteus vulgaris and Escherichia coli; site—directed mutagenesis causing impairment of export function Molec. Gen. Genet. 213 551–555PubMedGoogle Scholar
  117. Kotelko, K. 1986 Proteus mirabilis: Taxonomic position, peculiarities of growth, components of the cell envelope Curr. Top. Microbiol. Immunol. 129 181–215PubMedGoogle Scholar
  118. Krajden, S., M. Fuksa, W. Lizewski, L. Barton, and A. Lee. 1984 Proteus penneri and urinary calculi formation J. Clin. Microbiol. 19 541–542PubMedGoogle Scholar
  119. Krajden, S., M. Fuksa, C. Petrea, L. J. Crisp, and J. L. Penner. 1987 Expanded clinical spectrum of infections caused by Proteus penneri J. Clin. Microbiol. 25 578–579PubMedGoogle Scholar
  120. Kunin, C. M. 1989 Blockage of urinary catheters: role of microorganisms and constituents of the urine on formation of encrustations J. Clin. Epidemiol. 42 835–842PubMedGoogle Scholar
  121. Kusek, J. W., and L. G. Herman. 1980 Typing of Proteus mirabilis by bacteriocin production and sensitivity as a possible epidemiological marker J. Clin. Microbiol. 12 112–120PubMedGoogle Scholar
  122. Kusek, J. W., and L. G. Herman. 1981 Comparison of epidemiological methods for differentiation of Proteus mirabilis Am. J. Med. Technol. 47 835–840PubMedGoogle Scholar
  123. Kuwahara, H., Y. Miyamoto, T. Akaike, T. Kubota, T. Sawa, S. Okamoto, and H. Maeda. 2000 Helicobacter pylori urease suppresses bactericidal activity of peroxynitrite via carbon dioxide production Infect. Immun. 68 4378–4383PubMedGoogle Scholar
  124. Latta, R. K., M. J. Schur, D. L. Tolson, and E. Altman. 1998 The effect of growth conditions on in vitro adherence, invasion, and NAF expression by Proteus mirabilis 7570 Can. J. Microbiol. 44 896–904PubMedGoogle Scholar
  125. Latta, R. K., A. Grondin, H. C. Jarrell, G. R. Nicholls, and L. R. Berube. 1999 Differential expression of nonagglutinating fimbriae and MR/P pili in swarming colonies of Proteus mirabilis J. Bacteriol. 181 3220–3225PubMedGoogle Scholar
  126. Latuszynski, D. K., P. Schoch, M. T. Qadir, and B. A. Cunha. 1998 Proteus penneri urosepsis in a patient with diabetes mellitus Heart and Lung 27 146–148PubMedGoogle Scholar
  127. Lee, C. K., K. Soike, J. Hill, K. Georgakopoulos, T. Tibbitts, J. Ingrassia, H. Gray, J. Boden, H. Kleanthous, P. Giannasca, T. Ermak, R. Weltzin, J. Blanchard, and T. P. Monath. 1999 Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys Vaccine 17 1493–1505PubMedGoogle Scholar
  128. Legnani-Fajardo, C., P. Zunino, C. Piccini, A. Allen, and D. Maskell. 1996 Defined mutants of Proteus mirabilis lacking flagella cause ascending urinary tract infection in mice Microb. Pathog. 21 395–405PubMedGoogle Scholar
  129. Leifson, E., S. R. Carhart, and M. Fulton. 1955 Morphological characteristics of flagella of Proteus and related bacteria J. Bacteriol. 69 73–80PubMedGoogle Scholar
  130. Levina, L. A., E. V. Kholodkova, V. P. Raginskaia, and L. N. Kuborina. 1980 Serotyping of bacteria of the genus Providencia using the indirect hemagglutination test and the indirect hemagglutination inhibition test Zh. Mikrobiol. Epidemiol. Immunobiol. 5 100–103PubMedGoogle Scholar
  131. Li, Z., X. Wang, Z. Bian, S. Li, H. Zheng, B. Zhao, and J. Chen. 1992 Proteus penneri isolated from the pus of a patient with epidural abscess Kansenshogaku Zasshi 66 144–148PubMedGoogle Scholar
  132. Lilley, B. N., and B. L. Bassler. 2000 Regulation of quorum sensing in Vibrio harveyi by LuxO and sigma-54 Molec. Microbiol. 36 940–954Google Scholar
  133. Lin, M. Y., M. C. Cheng, K. J. Huang, and W. C. Tsai. 1993 Classification, pathogenicity, and drug susceptibility of hemolytic gram-negative bacteria isolated from sick or dead chickens Avian Dis. 37 6–9PubMedGoogle Scholar
  134. Lindum, P. W., U. Anthoni, C. Christophersen, L. Eberl, S. Molin, and M. Givskov. 1998 N-Acyl-L-homoserine lactone autoinducers control production of an extracellular lipopeptide biosurfactant required for swarming motility of Serratia liquefaciens MG1 J. Bacteriol. 180 6384–6388PubMedGoogle Scholar
  135. Lominski, I., and A. C. Lendrum. 1947 The mechanism of swarming of Proteus J. Pathol. Bacteriol. 59 688–691Google Scholar
  136. Loomes, L. M., B. W. Senior, and M. A. Kerr. 1990 A proteolytic enzyme secreted by Proteus mirabilis degrades immunoglobulins of the immunoglobulin A1 (IgA1), IgA2, and IgG isotypes Infect. Immun. 58 1979–1985PubMedGoogle Scholar
  137. Loomes, L. M., B. W. Senior, and M. A. Kerr. 1992 Proteinases of Proteus spp.: purification, properties, and detection in urine of infected patients Infect. Immun. 60 2267–2273PubMedGoogle Scholar
  138. Machtiger, N. A., and W. M. O’Leary. 1971 Nutritional requirements of Arizona, Citrobacter, and Providencia J. Bacteriol. 108 948–950PubMedGoogle Scholar
  139. Madico, G., N. S. Akopyants, and D. E. Berg. 1995 Arbitrarily primed PCR DNA fingerprinting of Escherichia coli O157:H7 strains by using templates from boiled cultures J. Clin. Microbiol. 33 1534–1536PubMedGoogle Scholar
  140. Maiden, M. C., J. A. Bygraves, E. Feil, G. Morelli, J. E. Russell, R. Urwin, Q. Zhang, J. Zhou, K. Zurth, D. A. Caugant, I. M. Feavers, M. Achtman, and B. G. Spratt. 1998 Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms Proc. Natl. Acad. Sci. USA 95 3140–3145PubMedGoogle Scholar
  141. Manafi, M., and M. L. Rotter. 1991 A new plate medium for rapid presumptive identification and differentiation of Enterobacteriaceae Int. J. Food Microbiol. 14 127–134PubMedGoogle Scholar
  142. Massad, G., C. V. Lockatell, D. E. Johnson, and H. L. Mobley. 1994 Proteus mirabilis fimbriae: Construction of an isogenic pmfA mutant and analysis of virulence in a CBA mouse model of ascending urinary tract infection Infect. Immun. 62 536–542PubMedGoogle Scholar
  143. Mathan, M. M., V. I. Mathan, and M. J. Albert. 1993 Electron microscopic study of the attachment and penetration of rabbit intestinal epithelium by Providencia alcalifaciens J. Pathol. 171 67–71PubMedGoogle Scholar
  144. Matsuyama, T., Y. Takagi, Y. Nakagawa, H. Itoh, J. Wakita, and M. Matsushita. 2000 Dynamic aspects of the structured cell population in a swarming colony of Proteus mirabilis J. Bacteriol. 182 385–393PubMedGoogle Scholar
  145. McCarter, L., M. Hilmen, and M. Silverman. 1988 Flagellar dynamometer controls swarmer cell differentiation of V. parahaemolyticus Cell 54 345–351PubMedGoogle Scholar
  146. McDermott, C., and J. M. Mylotte. 1984 Morganella morganii: Epidemiology of bacteremic disease Infect. Control 5 131–137PubMedGoogle Scholar
  147. McHale, P. J., C. T. Keane, and G. Dougan. 1981 Antibiotic resistance in Providencia stuartii isolated in hospitals J. Clin. Microbiol. 13 1099–1104PubMedGoogle Scholar
  148. McHale, P. J., F. Walker, B. Scully, L. English, and C. T. Keane. 1981 Providencia stuartii infections: A review of 117 cases over an eight year period J. Hosp. Infect. 2 155–165PubMedGoogle Scholar
  149. Menestrina, G., M. Dalla Serra, C. Pederzolli, M. Bregante, and F. Gambale. 1995 Bacterial hemolysins and leukotoxins affect target cells by forming large exogenous pores into their plasma membrane: Escherichia coli hemolysin A as a case example Biosci. Rep. 15 543–551PubMedGoogle Scholar
  150. Milazzo, F. H., and G. J. Delisle. 1984 Immunoglobulin A proteases in gram-negative bacteria isolated from human urinary tract infections Infect. Immun. 43 11–13PubMedGoogle Scholar
  151. Mino, Y., S. Kitano, S. Morimoto, and T. Ogihara. 1997 Urinary bacteria in elderly patients with urinary incontinence and low levels of daily activity Nippon Ronen Igakkai Zasshi 34 1004–1008PubMedGoogle Scholar
  152. Mobley, H. L., G. R. Chippendale, J. H. Tenney, and J. W. Warren. 1986 Adherence to uroepithelial cells of Providencia stuartii isolated from the catheterized urinary tract J. Gen. Microbiol. 132 2863–2872PubMedGoogle Scholar
  153. Mobley, H. L. T., and J. W. Warren. 1987 Urease-positive bacteriuria and obstruction of long-term urinary catheters J. Clin. Microbiol. 25 2216–2217PubMedGoogle Scholar
  154. Mobley, H. L., G. R. Chippendale, J. H. Tenney, A. R. Mayrer, L. J. Crisp, J. L. Penner, and J. W. Warren. 1988 MR/K hemagglutination of Providencia stuartii correlates with adherence to catheters and with persistence in catheter-associated bacteriuria J. Infect. Dis. 157 264–271PubMedGoogle Scholar
  155. Mobley, H. L., and R. P. Hausinger. 1989 Microbial ureases: Significance, regulation, and molecular characterization Microbiol. Rev. 53 85–108PubMedGoogle Scholar
  156. Mobley, H. L., and G. R. Chippendale. 1990 Hemagglutinin, urease, and hemolysin production by Proteus mirabilis from clinical sources J. Infect. Dis. 161 525–530PubMedGoogle Scholar
  157. Mobley, H. L., G. R. Chippendale, K. G. Swihart, and R. A. Welch. 1991 Cytotoxicity of the HpmA hemolysin and urease of Proteus mirabilis and Proteus vulgaris against cultured human renal proximal tubular epithelial cells Infect. Immun. 59 2036–2042PubMedGoogle Scholar
  158. Mobley, H. L., and R. Belas. 1995 Swarming and pathogenicity of Proteus mirabilis in the urinary tract Trends Microbiol. 3 280–284PubMedGoogle Scholar
  159. Mobley, H. L., R. Belas, V. Lockatell, G. Chippendale, A. L. Trifillis, D. E. Johnson, and J. W. Warren. 1996 Construction of a flagellum-negative mutant of Proteus mirabilis: Effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection Infect. Immun. 64 5332–5340PubMedGoogle Scholar
  160. Mohr O’Hara, C., A. G. Steigerwalt, D. Green, M. McDowell, B. C. Hill, D. J. Brenner, and J. M. Miller. 1999 Isolation of Providencia heimbachae from human feces J. Clin. Microbiol. 37 3048–3050PubMedGoogle Scholar
  161. Moltke, O. 1927 Decomposition of urea by Proteus Proc. Soc. Exp. Biol. Med. 47 108–112Google Scholar
  162. Morgan, H. D. R. 1906 Upon the bacteriology of the summer diarrhoea of infants Brit. Med. J. I 908–912Google Scholar
  163. Muder, R. R., C. Brennen, M. M. Wagener, and A. M. Goetz. 1992 Bacteremia in a long-term-care facility: A five-year prospective study of 163 consecutive episodes. Clin Infect. Dis. 14 647–654Google Scholar
  164. Muller, H. E. 1972 The aerobic flora of reptiles with special reference to the enterobacteria of snakes Zentralbl. Bakteriol. Parasitenkd. Infectionskr. Hyg. Abt. 1 Orig. 222 487–495Google Scholar
  165. Muller, H. E. 1983 Providencia friedericiana, a new species isolated from penguins Int. J. Syst. Bacteriol. 33 709–715Google Scholar
  166. Muller, H. E. 1986a Occurrence and pathogenic role of Morganella-Proteus-Providencia group bacteria in human feces J. Clin. Microbiol. 23 404–405PubMedGoogle Scholar
  167. Muller, H. E., C. M. O’Hara, G. R. Fanning, F. W. Hickman-Brenner, J. M. Swensen, and D. J. Brenner. 1986b Providencia heimbachae, a new species of Enterobacteriaceae isolated from animals Int. J. Syst. Bacteriol. 36 252–256Google Scholar
  168. Murphy, C. A., and R. Belas. 1999 Genomic rearrangements in the flagellin genes of Proteus mirabilis Molec. Microbiol. 31 679–690Google Scholar
  169. Musher, D. M., D. P. Griffith, D. Yawn, and R. D. Rossen. 1975 Role of urease in pyelonephritis resulting from urinary tract infection with Proteus J. Infect. Dis. 131 177–181PubMedGoogle Scholar
  170. Nealson, K. H. 1977 Autoinduction of bacterial luciferase: Occurrence, mechanism and significance Arch. Microbiol. 112 73–79PubMedGoogle Scholar
  171. Novak, S. S., and R. A. Seigel. 1986 Gram-negative septicemia in American alligators (Alligator mississippiensis) J. Wildl. Dis. 22 484–487PubMedGoogle Scholar
  172. Owen, R. J., A. Beck, P. A. Dayal, and C. Dawson. 1988 Detection of genomic variation in Providencia stuartii clinical isolates by analysis of DNA restriction fragment length polymorphisms containing rRNA cistrons J. Clin. Microbiol. 26 2161–2166PubMedGoogle Scholar
  173. Paradise, M. R., G. Cook, R. K. Poole, and P. N. Rather. 1998 Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2′-N-acetyltransferase Antimicrob. Agents Chemother. 42 959–962PubMedGoogle Scholar
  174. Parsek, M. R., and E. P. Greenberg. 2000 Acyl-homoserine lactone quorum sensing in gram-negative bacteria: A signaling mechanism involved in associations with higher organisms Proc. Natl. Acad. Sci. USA 97 8789–8793PubMedGoogle Scholar
  175. Peerbooms, P. G., A. M. Verweij, and D. M. MacLaren. 1983 Investigation of the haemolytic activity of Proteus mirabilis strains Ant. v. Leeuwenhoek 49 1–11Google Scholar
  176. Peerbooms, P. G., A. M. Verweij, and D. M. MacLaren. 1985 Uropathogenic properties of Proteus mirabilis and Proteus vulgaris J. Med. Microbiol. 19 55–60PubMedGoogle Scholar
  177. Penner, J. L., N. A. Hinton, G. R. Whiteley, and J. N. Hennessy. 1976 Variation in urease activity of endemic hospital strains of Proteus rettgeri and Providencia stuartii J. Infect. Dis. 134 370–376PubMedGoogle Scholar
  178. Penner, J. L., and J. N. Hennessy. 1979a Application of O-serotyping in a study of Providencia rettgeri (Proteus rettgeri) isolated from human and nonhuman sources J. Clin. Microbiol. 10 834–840PubMedGoogle Scholar
  179. Penner, J. L., and J. N. Hennessy. 1979b O antigen grouping of Morganella morganii (Proteus morganii) by slide agglutination J. Clin. Microbiol. 10 8–13PubMedGoogle Scholar
  180. Penner, J. L., P. C. Fleming, G. R. Whiteley, and J. N. Hennessy. 1979c O-serotyping Providencia alcalifaciens J. Clin. Microbiol. 10 761–765PubMedGoogle Scholar
  181. Penner, J. L., N. A. Hinton, I. B. Duncan, J. N. Hennessy, and G. R. Whiteley. 1979d O serotyping of Providencia stuartii isolates collected from twelve hospitals J. Clin. Microbiol. 9 11–14PubMedGoogle Scholar
  182. Penner, J. L., and J. N. Hennessy. 1980a Separate O-grouping schemes for serotyping clinical isolates of Proteus vulgaris and Proteus mirabilis J. Clin. Microbiol. 12 304–309PubMedGoogle Scholar
  183. Penner, J. L., and M. A. Preston. 1980b Differences among Providencia species in their in vitro susceptibilities to five antibiotics Antimicrob. Agents Chemother. 18 868–871PubMedGoogle Scholar
  184. Penner, J. L., M. A. Preston, J. N. Hennessy, L. J. Barton, and M. M. Goodbody. 1982 Species differences in susceptibilities of Proteeae spp. to six cephalosporins and three aminoglycosides Antimicrob. Agents Chemother. 22 218–221PubMedGoogle Scholar
  185. Penner, J. L. 1984 Genus XI Proteus In: N. R. Kreig and J. G. Holt (Ed.) [lcub;http://www.cme.msu.edu/bergeysrcub; lcub;Bergey’s Manual of Systematic Bacteriologyrcub;] Williams and Wilkins Baltimore MD 1 491–494Google Scholar
  186. Perch, B. 1948 On the serology of the Proteus group Acta Pathol. Microbiol. Scand. 25 703–714Google Scholar
  187. Phillips, J. E. 1955 In vitro studies of Proteus organisms of animal origin J. Hyg. (London) 53 26–31Google Scholar
  188. Piccolomini, R., L. Cellini, N. Allocati, A. Di Girolamo, and G. Ravagnan. 1987 Comparative in vitro activities of 13 antimicrobial agents against Morganella-Proteus-Providencia group bacteria from urinary tract infections Antimicrob. Agents Chemother. 31 1644–1647PubMedGoogle Scholar
  189. Piccolomini, R., A. Di Girolamo, G. Catamo, L. Cellini, N. Allocati, and G. Ravagnan. 1991 Enterosistem 18-R: Description and comparative evaluation with conventional methods for identification of members of the family Enterobacteriaceae J. Clin. Microbiol. 29 2300–2304PubMedGoogle Scholar
  190. Pignato, S., G. M. Giammanco, F. Grimont, P. A. D. Grimont, and G. Giammanco. 1999 Molecular characterisation of the genera Proteus, Morganella, and Providencia by ribotyping J. Clin. Microbiol. 37 2480–2487Google Scholar
  191. Pimenta, A. L., J. Young, I. B. Holland, and M. A. Blight. 1999 Antibody analysis of the localisation, expression and stability of HlyD, the MFP component of the E. coli haemolysin translocator Molec. Gen. Genet. 261 122–132PubMedGoogle Scholar
  192. Pompei, R., G. Cornaglia, A. Ingianni, and G. Satta. 1990 Use of a novel phosphatase test for simplified identification of species of the tribe Proteeae J. Clin. Microbiol. 28 1214–1218PubMedGoogle Scholar
  193. Prasad, L. B., and S. P. Pandey. 1966 Isolation of Proteus morganii from an atypical form of fatal gastro-enteritis in cattle Ind. Vet. J. 43 767–770Google Scholar
  194. Prentice, B., and B. L. Robinson. 1979 A review of Providencia bacteremia in a general hospital, with a comment on patterns of antimicrobial sensitivity and use Can. Med. Assoc. J. 121 745–749PubMedGoogle Scholar
  195. Radziejewska-Lebrecht, J., A. S. Shashkov, E. V. Vinogradov, H. Grosskurth, B. Bartodziejska, A. Rozalski, W. Kaca, L. O. Kononov, A. Y. Chernyak, H. Mayer, Y. A. Knirel, and N. K. Kochetkov. 1995 Structure and epitope characterisation of the O-specific polysaccharide of Proteus mirabilis O28 containing amides of D-galacturonic acid with L-serine and L-lysine Eur. J. Biochem. 230 705–712PubMedGoogle Scholar
  196. Rahav, G., E. Pinco, F. Silbaq, and H. Bercovier. 1994 Molecular epidemiology of catheter-associated bacteriuria in nursing home patients J. Clin. Microbiol. 32 1031–1034PubMedGoogle Scholar
  197. Rather, P. N., M. M. Parojcic, and M. R. Paradise. 1997 An extracellular factor regulating expression of the chromosomal aminoglycoside 2′-N-acetyltransferase of Providencia stuartii Antimicrob. Agents Chemother. 41 1749–1754PubMedGoogle Scholar
  198. Rauss, K. F. 1936 The systematic position of Morgan’s Bacillus J. Pathol. Bacteriol. 42 183–192Google Scholar
  199. Rauss, K., and S. Voros. 1959 The biochemical and serological properties of Proteus morganii Acta Microbiol. Acad. Sci. Hung. 14 233–248Google Scholar
  200. Rauss, K., and S. Voros. 1967a Antigenic relationships between Morganella morganii and different genera of Enterobacteriaceae Acta Microbiol. Acad. Sci. Hung. 14 199–204PubMedGoogle Scholar
  201. Rauss, K., and S. Voros. 1967b Five new serotypes of Morganella morganii Acta Microbiol. Acad. Sci. Hung. 14 195–198PubMedGoogle Scholar
  202. Rauss, K., H. Puzova, L. Dubay, D. Velin, M. Doliak, and S. Voros. 1975 New serotypes of Morganella morganii Acta Microbiol. Acad. Sci. Hung. 22 315–321PubMedGoogle Scholar
  203. Rietschel, E. T., T. Kirikae, F. U. Schade, U. Mamat, G. Schmidt, H. Loppnow, A. J. Ulmer, U. Zahringer, M. Schreier, and H. Brade. 1994 Bacterial endotoxin: Molecular relationships of structure to activity and function FASEB J. 8 217–225PubMedGoogle Scholar
  204. Rowen, J. L., and S. M. Lopez. 1998 Morganella morganii early onset sepsis Pediatr. Infect. Dis. J. 17 1176–1177PubMedGoogle Scholar
  205. Rozalski, A., H. Dlugonska, and K. Kotelko. 1986 Cell invasiveness of Proteus mirabilis and Proteus vulgaris strains Arch. Immunolog. Ther. Exp. 34 505–512Google Scholar
  206. Rozalski, A., and K. Kotelko. 1987 Hemolytic activity and invasiveness in strains of Proteus penneri J. Clin. Microbiol. 25 1094–1096PubMedGoogle Scholar
  207. Rozalski, A., Z. Sidorczyk, and K. Kotelko. 1997 Potential virulence factors of Proteus bacilli Microbiol. Molec. Biol. Rev. 61 65–89Google Scholar
  208. Rubin, R. H., N. E. Tolkoff-Rubin, and R. S. Cotran. 1986 Urinary tract infection, pyelonephritis and reflux nephropathy In: B. M. Brenner and F. C. Rector (Eds.) The Kidney W. B. Saunders Philadelphia PA 1085–1141Google Scholar
  209. Rudman, D., A. Hontanosas, Z. Cohen, and D. E. Mattson. 1988 Clinical correlates of bacteremia in a Veterans Administration extended care facility J. Am. Geriatr. Soc. 36 726–732PubMedGoogle Scholar
  210. Rustigian, R., and C. A. Stuart. 1945 The biochemical and serological relationships of the organisms of the genus Proteus J. Bacteriol. 49 419–436PubMedGoogle Scholar
  211. Satta, G., G. Grazi, P. E. Varaldo, and R. Fontana. 1979 Detection of bacterial phosphatase activity by means of an original and simple test J. Clin. Pathol. 32 391–395PubMedGoogle Scholar
  212. Schmidt, G., I. Fromme, and H. Mayer. 1970 Immunochemical studies on core lipopolysaccharides of Enterobacteriaceae of different genera Eur. J. Biochem. 14 357–366PubMedGoogle Scholar
  213. Schmidt, W. C., and C. D. Jeffries. 1974 Bacteriophage typing of Proteus mirabilis, Proteus vulgaris, and Proteus morganii Appl. Microbiol. 27 47–53PubMedGoogle Scholar
  214. Sekaninova, G., M. Hofer, I. Rychlik, J. Pillich, M. Kolarova, V. Zajicova, and D. Kubickova. 1994 A new phage typing scheme for Proteus mirabilis and Proteus vulgaris strains. 1. Morphological analysis Folia Microbiol. 39 381–386Google Scholar
  215. Sekaninova, G., I. Rychlik, M. Kolarova, J. Pillich, J. Semenka, and V. Zajicova. 1998 A new bacteriophage typing scheme for Proteus mirabilis and Proteus vulgaris strains. 3: Analysis of lytic properties Folia Microbiol. 43 136–140Google Scholar
  216. Sen, R. 1962 Isolation of strains of Providence group from cases with diarrhoea in Ibadan, Nigeria, West Africa Ind. J. Med. Res. 50 622–626Google Scholar
  217. Senior, B. W. 1979 The special affinity of particular types of Proteus mirabilis for the urinary tract J. Med. Microbiol. 12 1–8PubMedGoogle Scholar
  218. Senior, B. W. 1983 Proteus morganii is less frequently associated with urinary tract infections than Proteus mirabilis—an explanation J. Med. Microbiol. 16 317–322PubMedGoogle Scholar
  219. Senior, B. W., and D. L. Leslie. 1986 Rare occurrence of Proteus vulgaris in faeces: A reason for its rare association with urinary tract infections J. Med. Microbiol. 21 139–144PubMedGoogle Scholar
  220. Senior, B. W. 1987a The typing of Morganella morganii by bacteriocin production and sensitivity J. Med. Microbiol. 23 33–39PubMedGoogle Scholar
  221. Senior, B. W., M. Albrechtsen, and M. A. Kerr. 1987b Proteus mirabilis strains of diverse type have IgA protease activity J. Med. Microbiol. 24 175–180PubMedGoogle Scholar
  222. Senior, B. W., M. Albrechtsen, and M. A. Kerr. 1988 A survey of IgA protease production among clinical isolates of Proteeae J. Med. Microbiol. 25 27–31PubMedGoogle Scholar
  223. Senior, B. W., and S. Voros. 1989 Discovery of new morganocin types of Morganella morganii in strains of diverse serotype and the apparent independence of bacteriocin type from serotype of strains J. Med. Microbiol. 29 89–93PubMedGoogle Scholar
  224. Senior, B. W., and S. Voros. 1990 Protein profile typing—a new method of typing Morganella morganii strains J. Med. Microbiol. 33 259–264PubMedGoogle Scholar
  225. Senior, B. W. 1997 Media for the detection and recognition of the enteropathogen Providencia alcalifaciens in faeces J. Med. Microbiol. 46 524–527PubMedGoogle Scholar
  226. Serwecinska, L., T. Cieslikowski, M. Pytlos, A. Jaworski, and W. Kaca. 1998 Genomic fingerprinting of Proteus species using repetitive sequence based PCR (rep-PCR) Acta Microbiol. Pol. 47 313–319PubMedGoogle Scholar
  227. Shroff, K. E., K. Meslin, and J. J. Cebra. 1995 Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut Infect. Immun. 63 3904–3913PubMedGoogle Scholar
  228. Sidorczyk, Z., A. Swierzko, Y. A. Knirel, E. V. Vinogradov, A. Y. Chernyak, L. O. Kononov, M. Cedzynski, A. Rozalski, W. Kaca, A. S. Shashkov, and N. K. Kochetkov. 1995 Structure and epitope specificity of the O-specific polysaccharide of Proteus penneri strain 12 (ATCC 33519) containing the amide of D-galacturonic acid with L-threonine Eur. J. Biochem. 230 713–721PubMedGoogle Scholar
  229. Silverblatt, F. J. 1974 Host-parasite interaction in the rat renal pelvis: a possible role for pili in the pathogenesis of pyelonephritis J. Exp. Med. 140 1696–1711PubMedGoogle Scholar
  230. Silverblatt, F. J., and I. Ofek. 1978 Effects of pili on susceptibility of Proteus mirabilis to phagocytosis and on adherence to bladder cells In: E. H. Kass and W. Brumfitt (Eds.) Infections of the Urinary Tract University of Chicago Press Chicago IL 49–59Google Scholar
  231. Spira, W. M., R. B. Sack, and J. L. Froehlich. 1981 Simple adult rabbit model for Vibrio cholerae and enterotoxigenic Escherichia coli diarrhea Infect. Immun. 32 739–747PubMedGoogle Scholar
  232. Stevens, A. M., and E. P. Greenberg. 1998 Transcriptional activation by LuxR In: G. Dunny and S. C. Winans (Eds.) Cell-cell Signalling in Bacteria American Society for Microbiology Washington DC 231–242Google Scholar
  233. Stewart, B. J., J. L. Enos-Berlage, and L. L. McCarter. 1997 The lonS gene regulates swarmer cell differentiation of Vibrio parahaemolyticus J. Bacteriol. 179 107–114PubMedGoogle Scholar
  234. Stickler, D. J., C. Fawcett, and J. C. Chawla. 1985 Providencia stuartii: A search for its natural habitat J. Hosp Infect. 6 221–3PubMedGoogle Scholar
  235. Stickler, D., N. Morris, M. C. Moreno, and N. Sabbuba. 1998 Studies on the formation of crystalline bacterial biofilms on urethral catheters Eur. J. Clin. Microbiol. Infect. Dis. 17 649–652PubMedGoogle Scholar
  236. Stickler, D., and G. Hughes. 1999 Ability of Proteus mirabilis to swarm over urethral catheters Eur. J. Clin. Microbiol. Infect. Dis. 18 206–208PubMedGoogle Scholar
  237. Stock, I., and B. Wiedemann. 1998 Natural antibiotic susceptibility of Providencia stuartii, P. rettgeri, P. alcalifaciens, and P. rustigianii strains J. Med. Microbiol. 47 629–642PubMedGoogle Scholar
  238. Story, P. 1954 Proteus infections in hospitals J. Pathol. Bacteriol. 68 55–62PubMedGoogle Scholar
  239. Swiatlo, E., and F. E. Kocka. 1987 Inducible expression of an aminoglycoside-acetylating enzyme in Providencia stuartii J. Antimicrob. Chemother. 19 27–30PubMedGoogle Scholar
  240. Swihart, K. G., and R. A. Welch. 1990a Cytotoxic activity of the Proteus hemolysin HpmA Infect. Immun. 58 1861–1869PubMedGoogle Scholar
  241. Swihart, K. G., and R. A. Welch. 1990b The HpmA hemolysin is more common than HlyA among Proteus isolates Infect. Immun. 58 1853–1860PubMedGoogle Scholar
  242. Tanaka, M., H. Takuma, N. Kokumai, E. Oishi, T. Obi, K. Hiramatsu, and Y. Shimizu. 1995 Turkey rhinotracheitis virus isolated from broiler chicken with swollen head syndrome in Japan J. Vet. Med. Sci. 57 939–941PubMedGoogle Scholar
  243. Telford, G., D. Wheeler, P. Williams, P. T. Tomkins, P. Appleby, H. Sewell, G. S. Stewart, B. W. Bycroft, and D. I. Pritchard. 1998 The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity Infect. Immun. 66 36–42PubMedGoogle Scholar
  244. Thaller, M. C., F. Berlutti, F. Pantanella, R. Pompei, and G. Satta. 1992 Modified MacConkey medium which allows simple and reliable identification of Providencia stuartii J. Clin. Microbiol. 30 2054–2057PubMedGoogle Scholar
  245. Thibault, P., and L. Le Minor. 1957 Méthodes simples de recherche de la lysine-décarboxylase et de la tryptophane-déaminase à l’aide des milieux pour differenciation rapide des Enterobacteriacées Ann. Inst. Pasteur 92 551–554Google Scholar
  246. Thompson, J. D., D. G. Higgins, and T. J. Gibson. 1994 CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice Nucl. Acids Res. 22 4673–4680PubMedGoogle Scholar
  247. Thornton, S. M., S. Nolan, and F. M. Gulland. 1998 Bacterial isolates from California sea lions (Zalophus californianus), harbor seals (Phoca vitulina), and northern elephant seals (Mirounga angustirostris) admitted to a rehabilitation center along the central California coast, 1994–1995 J. Zoo. Wildl. Med. 29 171–176PubMedGoogle Scholar
  248. Tolson, D. L., D. L. Barrigar, R. J. McLean, and E. Altman. 1995 Expression of a nonagglutinating fimbria by Proteus mirabilis Infect. Immun. 63 1127–1129PubMedGoogle Scholar
  249. Tolson, D. L., B. A. Harrison, R. K. Latta, K. K. Lee, and E. Altman. 1997 The expression of nonagglutinating fimbriae and its role in Proteus mirabilis adherence to epithelial cells Can. J. Microbiol. 43 709–717PubMedGoogle Scholar
  250. Wachowicz, B., J. Saluk, and W. Kaca. 1998 Response of blood platelets to Proteus mirabilis lipopolysaccharide Microbiol. Immunol. 42 47–49PubMedGoogle Scholar
  251. Walker, K. E., S. Moghaddame-Jafari, C. V. Lockatell, D. Johnson, and R. Belas. 1999 ZapA, the IgA-degrading metalloprotease of Proteus mirabilis, is a virulence factor expressed specifically in swarmer cells Molec. Microbiol. 32 825–836Google Scholar
  252. Warren, J. W. 1986 Providencia stuartii: A common cause of antibiotic-resistant bacteriuria in patients with long-term indwelling catheters Rev. Infect. Dis. 8 61–67PubMedGoogle Scholar
  253. Warren, J. W. 1987a Catheter-associated urinary tract infections Infect. Dis. Clin. N. Am. 1 823–854Google Scholar
  254. Warren, J. W., D. Damron, J. H. Tenney, J. M. Hoopes, B. Deforge, and H. L. Muncie Jr. 1987b Fever, bacteremia, and death as complications of bacteriuria in women with long-term urethral catheters J. Infect. Dis. 155 1151–1158PubMedGoogle Scholar
  255. Wassif, C., D. Cheek, and R. Belas. 1995 Molecular analysis of a metalloprotease from Proteus mirabilis J. Bacteriol. 177 5790–5798PubMedGoogle Scholar
  256. Weber, G., D. Heck, R. R. Bartlett, and K. Nixdorff. 1992 Modulation of effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis as measured in a chemiluminescence assay Infect. Immun. 60 1069–1075PubMedGoogle Scholar
  257. Weber, G., F. Link, E. Ferber, P. G. Munder, D. Zeitter, R. R. Bartlett, and K. Nixdorff. 1993 Differential modulation of the effects of lipopolysaccharide on macrophages by a major outer membrane protein of Proteus mirabilis J. Immunol. 151 415–424PubMedGoogle Scholar
  258. Welch, R. A., E. P. Dellinger, B. Minshew, and S. Falkow. 1981 Haemolysin contributes to virulence of extra-intestinal E. coli infections Nature 294 665–667PubMedGoogle Scholar
  259. Welch, R. A. 1987 Identification of two different hemolysin determinants in uropathogenic Proteus isolates Infect. Immun. 55 2183–2190PubMedGoogle Scholar
  260. Wenner, J. J., and L. F. Retger. 1919 A systematic study of the Proteus group of bacteria J. Bacteriol. 4 331–353PubMedGoogle Scholar
  261. Williams, F. D., D. M. Anderson, P. S. Hoffman, R. H. Schwarzhoff, and S. Leonard. 1976 Evidence against the involvement of chemotaxis in swarming of Proteus mirabilis J. Bacteriol. 127 237–248PubMedGoogle Scholar
  262. Williams, F. D., and R. H. Schwarzhoff. 1978 Nature of the swarming phenomenon in Proteus Ann. Rev. Microbiol. 32 101–122Google Scholar
  263. Woods, T. D., and C. Watanakunakorn. 1996 Bacteremia due to Providencia stuartii: review of 49 episodes South. Med. J. 89 221–224PubMedGoogle Scholar
  264. Young, G. M., D. Amid, and V. L. Miller. 1996 A bifunctional urease enhances survival of pathogenic Yersinia enterocolitica and Morganella morganii at low pH J. Bacteriol. 178 6487–6495PubMedGoogle Scholar
  265. Zunino, P., C. Piccini, and C. Legnani-Fajardo. 1994 Flagellate and non–flagellate Proteus mirabilis in the development of experimental urinary tract infection Microb. Pathog. 16 379–385PubMedGoogle Scholar
  266. Zych, K., and Z. Sidorczyk. 1989 Lipopolysaccharides of Proteus penneri species novum Carbohydr. Res. 188 105–111PubMedGoogle Scholar

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© Springer-Verlag 2006

Authors and Affiliations

  • Jim Manos
  • Robert Belas

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