Handbook of Nuclear Chemistry pp 1345-1377 | Cite as
Cyclotron Production of Medical Radionuclides
Introduction
Radionuclides find application in many fields. Their major use is, however, in medicine, both in diagnosis and therapy. The production of radionuclides is carried out using nuclear reactors as well as cyclotrons. The reactor produced radionuclides are generally neutron excess nuclides. They mostly decay by β− emission. The cyclotron produced radionuclides, on the other hand, are often neutron deficient and decay mainly by EC or β+ emission. They are especially suitable for diagnostic studies. The reactor production of radionuclides is described in Chapter 1 of this Volume; this chapter treats the production with cyclotrons. It is worth pointing out that today more than 250 cyclotrons exist worldwide (cf. Directory of Cyclotrons, IAEA-DCRP/CD, 2002), many of them in hospitals, which produce short-lived radionuclides for medical use. Thus the radionuclide production science and technology at cyclotrons has become a very important feature of modern nuclear medicine.
Whereas...
Keywords
Positron Emission Tomography Excitation Function Production Route Radioactive Product 124I ImpurityReferences to Cyclotron Production of Medical Radionuclides
- BAKIR, M. A., BABICH, J. W., STYLES, J. M., DEAN, C. J., ECCLES, S. A., LAMBRECHT, R. M., 1990, J. Nucl. Med., 31, 777.Google Scholar
- BASTIAN, TH., COENEN, H. H., QAIM, S. M., 2001, Appl. Radiat. Isot., 55, 303.CrossRefGoogle Scholar
- BECKER, D., BUCKLEY, K. R., CHUN, K. S., HURTADO, E. T., JIVAN, S., ZEISLER, S., RUTH, T. J., 2001, J. Lab. Compds. Radiopharm., 44, 122.Google Scholar
- BEYER, G.-J., PIMENTEL-GONZALES, G., 2000, Radiochim. Acta, 88, 175.Google Scholar
- BIDA, G., EHRENKAUFER, R. L., WOLF, A. P., FOWLER, J. S., MACGREGOR, R. R., RUTH, T. J., 1980, J. Nucl. Med., 21, 758.Google Scholar
- BISHOP, A., SATYAMURTHY, N., BIDA, G., PHELPS, M., BARRIO, J. R., 1996, Nucl. Med. Biol., 23, 391.CrossRefGoogle Scholar
- BLESSING, G., QAIM, S. M., 1984, Int. J. Appl. Radiat. Isot., 35, 927.CrossRefGoogle Scholar
- BLESSING, G., COENEN, H. H., FRANKEN, K., QAIM, S. M., 1986, Appl. Radiat. Isot., 37, 1135.Google Scholar
- BLESSING, G., LAVI, N., HASHIMOTO, K., QAIM, S. M., 1994, Radiochim. Acta, 65, 93.Google Scholar
- BLESSING, G., TÁRKÁNYI, F., QAIM, S. M., 1997, Appl. Radiat. Isot., 48, 37.CrossRefGoogle Scholar
- BROWNE, E., FIRESTONE, R. B., 1986, Table of Radioactive Isotopes, edited by V. S. Shirley, (New York: Wiley).Google Scholar
- CASELLA, V., IDO, T., WOLF, A. P., FOWLER, J. S., MACGREGOR, R. R., RUTH, T. J., 1980, J. Nucl. Med., 21, 750.Google Scholar
- CROUZEL, C., LANGSTRÖM, B., PIKE, V. W., COENEN, H. H., 1987, Appl. Radiat. Isot., 38, 601.CrossRefGoogle Scholar
- FERRIERI, R. A., WOLF, A. P., 1983, Radiochim. Acta, 34, 69.Google Scholar
- FIROUZBAKHT, M. L., SCHLYER, D. J., GATLEY, S. J., WOLF, A. P., 1993, Appl. Radiat. Isot., 44, 1081.CrossRefGoogle Scholar
- GAMESTANI, K., MILENIC, D. E., PLASCJAK, P. S., BRECHBIEL, M. W., 2002, Nucl. Med. Biol., 29, 599.CrossRefGoogle Scholar
- GUL, K., HERMANNE, A., MUSTAFA, M.G., NORTIER, F.M., OBLOZINSKY, P., QAIM, S. M., SCHOLTEN,B., SHUBIN, Y., TAKÁCS, S., TÁRKÁNYI, F. T., ZHUANG, Y., 2001, Charged Particle Cross Section Database for Medical Radioisotope Production, IAEA-Tecdoc-1211, Vienna, pp. 1–284.Google Scholar
- HAMACHER, K., HIRSCHFELDER, T., COENEN, H. H., 2002, Appl. Radiat. Isot., 56, 519.CrossRefGoogle Scholar
- HERMANNE, A., GUL, K., MUSTAFA, M.g., NORTIER, F.m., OBLOZINSKY, P., QAIM, S. M., SCHOLTEN, B., TAKÁCS, S., TÁRKÁNYI, F., 2001, Photon Emitters, in Charged Particle Cross Section Database for Medical Radioisotope Production, IAEA-Tecdoc-1211, Vienna, pp. 153–233.Google Scholar
- HESELIUS, S.-J., 1986, Studies of Density Reduction in Gas Targets, PhD Thesis, Abo Akademi: Abo, Finland.Google Scholar
- HESELIUS, S.-J., SCHLYER, D.J., WOLF, A. P., 1989, J. Lab. Compds. Radiopharm., 26, 140.Google Scholar
- HESS, E., BLESSING, G., COENEN, H. H., QAIM, S. M., 2000, Appl. Radiat. Isot., 52, 1431.CrossRefGoogle Scholar
- HESS, E., TAKÁCS, S., SCHOLTEN, B., TÁRKÁNYI, F., COENEN, H. H., QAIM, S. M., 2001, Radiochim. Acta, 89, 357.Google Scholar
- HOHN, A., SCHOLTEN, B., COENEN, H. H., QAIM, S. M., 1998a, Appl. Radiat. Isot., 49, 93.CrossRefGoogle Scholar
- HOHN, A., COENEN, H. H., QAIM, S. M., 1998b, Appl. Radiat. Isot., 49, 1493.CrossRefGoogle Scholar
- HOHN, A., NORTIER, F. M., SCHOLTEN, B., VAN DER WALT, T.N., COENEN, H.H., QAIM, S. M., 2001, Appl. Radiat. Isot., 55, 149.CrossRefGoogle Scholar
- KASTLEINER, S., COENEN, H. H., QAIM, S. M., 1999, Radiochim. Acta, 84, 107.Google Scholar
- KETTERN, K., LINSE, K.-H., SPELLERBERG, S., COENEN, H. H., QAIM, S. M., 2002, Radiochim. Acta, 90, 845.CrossRefGoogle Scholar
- KILBOURN, M. R., JERABEK, P. A., WELCH, M. J., 1985, Int. J. Appl. Radiat. Isot., 36, 327.CrossRefGoogle Scholar
- KNUST, E. J., DUTSCHKA, K., WEINREICH, R., 2000, Appl. Radiat. Isot., 52, 181.CrossRefGoogle Scholar
- KONDO, K., LAMBRECHT, R. M., WOLF, A. P., 1977, Int. J. Appl. Radiat. Isot., 28, 395.CrossRefGoogle Scholar
- KOVÁCS, Z., BLESSING, G., QAIM, S. M., STÖCKLIN, G., 1985, Int. J. Appl. Radiat. Isot., 36, 635.CrossRefGoogle Scholar
- KURENKOV, N. V., MALININ, A. B., SEBYAKIN, A. A., VENIKOV, N. I., 1989, J. Radioanalyt. Nucl. Chem. Lett., 135, 39.CrossRefGoogle Scholar
- LAGUNAS-SOLAR, M. C., JUNGERMAN, J. A., PEEK, N. F., THEUS, R. M., 1978, Int. J. Appl. Radiat. Isot., 29, 159.CrossRefGoogle Scholar
- LAMBRECHT, R. M., MIRZADEH, S., 1985, Int. J. Appl. Radiat. Isot., 36, 443.CrossRefGoogle Scholar
- LAMBRECHT, R. M., SAJJAD, M., QURESHI, M. A., AL-YANBAWI, S. J., 1988, J. Radioanalyt. Nucl. Chem. Lett., 127, 143.CrossRefGoogle Scholar
- LOC'H,, C., MARDON, K., VALETTE, H., BRURESCO, C., MERLET, P., SYROTA, A., MAZIERE, B., 1994, Nucl. Med. Biol., 21.Google Scholar
- MAHUNKA, I., ANDÓ, L., GÁL, I., IDO, T., KOVÁCS, Z., 1996, in Proc. 6th Workshop on Targetry and Target Chemistry, Vancouver, Canada, August 1995, (edited by J. M. Link and T. J. Ruth), TRIUMF, p. 192.Google Scholar
- MCCARTHY, T.J., itor, 2000, Proceedings of the 8th Workshop on Targetry and Target Chemistry, St. Louis, Usa, June 1999, pp. 1–209.Google Scholar
- MCCARTHY, D.W., SHEFER, R. E., KLINKOWSTEIN, R. E., BASS, L. A., MARGENEAU, W. H., CUTLER, C. S., ANDERSON, C. J., WELCH, M. J., 1997, Nucl. Med. Biol., 24, 35.CrossRefGoogle Scholar
- MICHAEL, H., ROSEZIN, H., APELT, H., BLESSING, G., KNIEPER, J., QAIM, S. M., 1981, Int. J. Appl. Radiat. Isot., 32, 581.CrossRefGoogle Scholar
- MIRZADEH, S., MAUSNER, L. F., SRIVASTAVA, S. C., 1986, Appl. Radiat. Isot., 37, 29.Google Scholar
- MUSHTAQ, A., QAIM, S. M., STÖCKLIN, G., 1988, Appl. Radiat. Isot., 39, 1085.Google Scholar
- NAGATSU, K., KUBODERA, A., SUZUKI, K., 1998, Appl. Radiat. Isot., 49, 1505.CrossRefGoogle Scholar
- NICKLES, R.J., HICHWA, R., DAUBE, M.E., HUTCHINS, G. D., CONGDON, D.D., 1983, Appl. Radiat. Isot., 34, 625.CrossRefGoogle Scholar
- PHILIPPS, D.R., PETERSON, E. J., TAYLOR, W. A., JAMRISKA, D.J., HAMILTON, V.T., Kitten, J.j., VALDEZ, F.O., SALAZAR, L.L., PITT, L.R., HEATON, R.C., KOLSKY, K.L., MAUSNER, L.F., KURCZAK, S., ZHUIKOV, B.L., KOKHANYUK, V.M., KONYAKHIN, N.A., NORTIER, F.M., VAN DER WALT, T.N., HANEKOM, J., SOSNOWSKI, K.M., CARTY, J.S., 2000, Radiochim. Acta, 88, 149.Google Scholar
- PLENEVAUX, A., GUILLAUME, M., BRIHAYE, C., LEMAIRE, C., CANTINEAU, R., 1990, Appl. Radiat. Isot., 41, 829.Google Scholar
- QAIM, S. M., 1982, Radiochim. Acta, 30, 147.Google Scholar
- QAIM, S. M., 1986, Int. J. Appl. Radiat. Isot., 37, 803.CrossRefGoogle Scholar
- QAIM, S. M., 1987, Radiochim. Acta, 41, 111.Google Scholar
- QAIM, S. M., 1989, Nucl. Instr. Methods, 282, 289.CrossRefGoogle Scholar
- QAIM, S. M., 2000, J. Nucl. Med. Biol., 27, 323.CrossRefGoogle Scholar
- QAIM, S. M., (editor), 2001a, Nuclear Data for Medical Applications. Special issue of Radiochim. Acta, 89, pp. 189–355.Google Scholar
- QAIM, S. M., 2001b, Radiochim. Acta, 89, 297.Google Scholar
- QAIM, S. M., 2002, J. Nucl. Sci. Technology, Supplement 2, 1272.Google Scholar
- QAIM, S. M., CLARK, J. C., CROUZEL, C., GUILLAUME, M., HELMEKE, H. J., NEBELING, B., PIKE, V. W., STÖCKLIN, G., 1993, PET Radionuclide Production, in Radiopharmaceuticals for Positron Emission Tomography, edited by G. Stöcklin and V. W. Pike, (Dordrecht, The Netherlands: Kluwer) pp. 1–42.Google Scholar
- QAIM, S. M., HOHN, A., BASTIAN, T., EL-AZONEY, K. M., BLESSING, G., SPELLERBERG, S., SCHOLTEN, B., COENEN, H. H., 2003, Appl. Radiat. Isot. 58, 69.CrossRefGoogle Scholar
- QAIM, S. M., TÁRKÁNYI, F.t., OBLOZINSKÝ, P., GUL, K., HERMANNE, A., MUSTAFA, M. G., NORTIER, F. M., SCHOLTEN, B., SHUBIN, Yu.N., TAKÁCS, S., ZHUANG, Y., 2002, J. Nucl. Sci. Technology, Supplement 2, 1281.Google Scholar
- QAIM, S. M., TÁRKÁNYI, F., TAKÁCS, S., HERMANNE, A., NORTIER, M., OBLOZINSKY, P., SCHOLTEN, B., SHUBIN, Y. N., ZHUANG, Y., 2001, Positron Emitters, in Charged Particle Cross Section Database for Medical Radioisotope Production, IAEA-Tecdoc-1211, Vienna, pp 234–280.Google Scholar
- QAIM, S. M., WEINREICH, R., OLLIG, H., 1979, Int. J. Appl. Radiat. Isot., 30, 85.CrossRefGoogle Scholar
- REISCHL, G., RÖSCH, F., MACHULLA, H.-J., 2002, Radiochim. Acta, 90, 225.CrossRefGoogle Scholar
- ROBERTS, A. D., OAKES, T. R., NICKLES, R. J., 1995, Appl. Radiat. Isot., 46, 82.CrossRefGoogle Scholar
- RÖSCH, F., QAIM, S. M., STÖCKLIN, G., 1993a, Radiochim. Acta, 61, 1.Google Scholar
- RÖSCH, F., QAIM, S. M., STÖCKLIN, G., 1993b, Appl. Radiat. Isot., 44, 671.CrossRefGoogle Scholar
- RÖSCH, F., NOVGORODOV, A. F., QAIM, S. M., 1994, Radiochim. Acta, 64, 113.Google Scholar
- RUTH, T. J., 1985, Int. J. Appl. Radiat. Isot., 36, 107.CrossRefGoogle Scholar
- RUTH, T. J., 2003, Accelerators available for isotope production, in Handbook of Radiopharmaceuticals, edited by M. J. Welch and C. S. Redvanly, (Chichester: Wiley) pp. 71–83.Google Scholar
- RUTH, T. J., WOLF, A. P., 1979, Radiochim. Acta, 26, 21.Google Scholar
- SCHOLTEN, B., KOVÁCS, Z., TÁRKÁNYI, F., QAIM, S. M., 1995, Appl. Radiat. Isot., 46, 255.CrossRefGoogle Scholar
- SCHOLTEN, B., QAIM, S. M., STÖCKLIN, G., 1989, Appl. Radiat. Isot., 40, 127.Google Scholar
- SCHLYER, D. J., 2003, Production of radionuclides in accelerators, in Handbook of Radiopharmaceuticals, edited by M. J. Welch and C. S. Redvanly, (Chichester: Wiley) pp. 1–70.Google Scholar
- SCHWARZBACH, R., ZIMMERMANN, K., BLÄUENSTEIN, P., SMITH, A., SCHUBIGER, P. A., 1995, Appl. Radiat. Isot., 46, 329.CrossRefGoogle Scholar
- SHARMA, H. L., ZWEIT, J., DOWNEY, S., SMITH, A. M., SMITH, A. G., 1998, J. Lab. Compds. Radiopharm., 26, 165.Google Scholar
- SHEH, Y., KOZIOROWSKI, J., BALATONI, J., LOM, C., DAHL, J. R., FINN, R. D., 2000, Radiochim. Acta, 88, 169.Google Scholar
- SHIGETA, N., MATSUOKA, H., OSA, A., KOIZUMI, M., IZUMO, M., KOBAYASHI, K., HASHIMOTO, K., LAMBRECHT, R. M., 1996, J. Radioanalyt. Nucl. Chem. Articles, 205, 85.CrossRefGoogle Scholar
- SPELLERBERG, S., REIMER, P., BLESSING, G., COENEN, H. H., QAIM, S. M., 1998, Appl. Radiat. Isot., 49, 1519.CrossRefGoogle Scholar
- STÖCKLIN, G., QAIM, S. M., RÖSCH, F., 1995, Radiochim. Acta, 70/71, 249.Google Scholar
- STOLL, T., KASTLEINER, S., SHUBIN, YU.N., COENEN, H.H., QAIM, S. M., 2001, Radiochim. Acta, 90, 309.CrossRefGoogle Scholar
- STROHMAIER, B., FASSBENDER, M., QAIM, S. M., 1997, Phys. Rev. C, 56, 2654.Google Scholar
- SUDÁR, S., CSERPÁK, F., QAIM, S. M., 2002, Appl. Radiat. Isot., 56, 821.CrossRefGoogle Scholar
- SUZUKI, K., YAMAZAKI, I., SASAKI, M., KUBODERA, A., 2000, Radiochim. Acta, 88, 211.Google Scholar
- SZELECSÉNYI, F., BLESSING, G., QAIM, S. M., 1993, Appl. Radiat. Isot., 44, 575.CrossRefGoogle Scholar
- SZELECSÉNYI, F., TAKÁCS, S., TÁRKÁNYI, F., SONCK, M., HERMANNE, A., 1999, J. Lab. Compds. Radiopharm., 42, 912.Google Scholar
- TÁRKÁNYI, F., QAIM, S. M., STÖCKLIN, G., SAJJAD, M., LAMBRECHT, R. M., SCHWEICKERT, H., 1991, Appl. Radiat. Isot., 42, 221.CrossRefGoogle Scholar
- TÁRKÁNYI, F., SZELECSÉNYI, F., KOPECKY, P., MOLNÁR, T., ANDÓ, L., MIKECZ, P., TÓTH, G. Y., RYDL, A., 1994, Appl. Radiat. Isot., 45, 239.CrossRefGoogle Scholar
- TÁRKÁNYI, F., SZELECSÉNYI, F., KOVÁCS, Z., SUDÁR, S.0, 1990, Radiochim. Acta, 50, 19.Google Scholar
- TOLMACHEV, V., LÖVQVIST, A., EINARSSON, L., SCHULTZ, J., LUNDQVIST, H., 1998, Appl. Radiat. Isot., 49, 1537.CrossRefGoogle Scholar
- VAALBURG, W., PAANS, A. M. J., TERPSTRA, J. W., WIEGMAN, T., DEKENS, K., RIJSKAMP, A., WOLDRING, M. G., 1985, Int. J. Appl. Radiat. Isot., 36, 961.CrossRefGoogle Scholar
- VAN DEN BOSCH, R., DE GOEIJ, J.J. M., VAN DER HEIDE, J.A., TERTOOLEN, J.F.W., THEELEN, H.M.J., ZEGERS, C., 1977, Int. J. Appl. Radiat. Isot., 28, 255.CrossRefGoogle Scholar
- WATERS S.L. COURSEY B. M. itors 1987 The 82Sr/82Rb generator Special issue of Appl. Radiat. Isot. 38 pp. 171–24Google Scholar
- WEINREICH, R., KNUST, E. J., 1996, J. Radioanalyt. Nucl. Che . Lett., 213, 253CrossRefGoogle Scholar
- WIELAND, B. W., SCHLYER, D. J., WOLF, A. P., 1984, Int. J. Appl. Radiat. Isot., 35, 387.CrossRefGoogle Scholar
- WOLF, A.P., BARCLAY JONES, W., 1983, Radiochim. Acta, 34, 1.Google Scholar
- ZEISLER, S. K., BECKER, D. W., PAVAN, R. A., MOSCHEL, R., RÜHLE, H., 2000, Appl. Radiat. Isot., 53, 449.CrossRefGoogle Scholar
- ZHANG, A., LI, W., FANG, K., HE, W., SHENG, R., YING, D., HU, W., 1999, Radiochim. Acta, 86, 11.Google Scholar
- ZHANG, X., LI, Q., LI, W., SHENG, R., SHEN, S., 2001, Appl. Radiat. Isot., 54, 89.CrossRefGoogle Scholar