Skip to main content
SpringerLink
Log in

Herpesvirus-Infektionen bei Kindern und Jugendlichen

  • Living reference work entry
  • First Online:
Pädiatrie

Part of the book series: Springer Reference Medizin ((SRM))

  • 113 Accesses

Zusammenfassung

Alle Viren der Herpesvirus-Gruppe persistieren im Wirtsorganismus nach Erstinfektion lebenslang. Bei Immunsuppression verlaufen Infektionen mit Herpesviren besonders schwer. Infektionen mit Herpes-simplex-Virus Typ 1 und 2 (HSV-1 und -2) führen u. a. zu schweren neonatalen Infektionen und Herpesenzephalitis. Bei Infektionen mit dem Varicella-Zoster-Virus (VZV) sind u. a. neonatale VZV-Infektionen, Enzephalitis, ZNS-Vaskulitis und Herpes zoster gefürchtet. Das Epstein-Barr-Virus (EBV) ist der Erreger der infektiösen Mononukleose. Bei Immunsuppression können lebensbedrohliche lymphoproliferative Krankheitsbilder auftreten. Beim Zytomegalievirus (CMV) ist die konnatale Zytomegalie gefürchtet. Die humanen Herpesviren (HHV) 6 und 7 verursachen das Dreitagefieber und das HHV8 ist mit dem Kaposi-Sarkom assoziiert. Seit längerem existiert eine wirksame Impfung gegen VZV. Gegen HSV und VZV sind Aciclovir und Valaciclovir wirksam, gegen CMV Ganciclovir und Valganciclovir.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Weiterführende Literatur

  • Ali S, AlThubaiti S, Renzi S, Krueger J, Chiang KY, Naqvi A, Schechter T, Punnett A, Ali M (2019) Hemophagocytic lymphohistiocytosis is a sign of poor outcome in pediatric Epstein-Barr virus-associated post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation. Pediatr Transplant 23(1):e13319

    Article  Google Scholar 

  • Amlie-Lefond C, Gilden D (2016) Varicella Zoster virus: a common cause of stroke in children and adults. J Stroke Cerebrovasc Dis 25(7):1561–1569

    Article  Google Scholar 

  • Anderson LA, Li Y, Graubard BI, Whitby D, Mbisa G, Tan S, Goedert JJ, Engels EA (2008) Human herpesvirus 8 seroprevalence among children and adolescents in the United States. Pediatr Infect Dis J 27(7):661–664

    Article  Google Scholar 

  • Bapistella S, Hamprecht K, Thomas W, Speer CP, Dietz K, Maschmann J, Poets CF, Goelz R (2018) Short-term pasteurization of breast milk to prevent postnatal cytomegalovirus transmission in very preterm infants. Clin Infect Dis. https://doi.org/10.1093/cid/ciy945

    Article  Google Scholar 

  • Bowman LJ, Brueckner AJ, Doligalski CT (2018) The role of mTOR inhibitors in the management of viral infections: a review of current literature. Transplantation 102(2S Suppl 1):S50–S59

    Article  CAS  Google Scholar 

  • Byun M, Abhyankar A, Lelarge V, Plancoulaine S, Palanduz A, Telhan L, Boisson B, Picard C, Dewell S, Zhao C, Jouanguy E, Feske S, Abel L, Casanova JL (2010) Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. J Exp Med 207(11):2307–2312

    Article  CAS  Google Scholar 

  • Cameron BM, Kennedy SE, Rawlinson WD, Mackie FE (2017) The efficacy of valganciclovir for prevention of infections with cytomegalovirus and Epstein-Barr virus after kidney transplant in children. Pediatr Transplant 21(1). https://doi.org/10.1111/petr.12816

    Article  Google Scholar 

  • Centers for Disease Control and Prevention (CDC) (2013) Updated recommendations for use of VariZIG--United States, 2013. MMWR Morb Mortal Wkly Rep 62(28):574–576

    Google Scholar 

  • Chen RL, Lin JC, Wang PJ, Lee CP, Hsu YH (2004) Human herpesvirus 8-related childhood mononucleosis: a series of three cases. Pediatr Infect Dis J 23(7):671–674

    Article  Google Scholar 

  • Dunmire SK, Verghese PS, Balfour HH Jr (2018) Primary Epstein-Barr virus infection. J Clin Virol 102:84–92

    Article  Google Scholar 

  • Epstein LG, Shinnar S, Hesdorffer DC, Nordli DR, Hamidullah A, Benn EK, Pellock JM, Frank LM, Lewis DV, Moshe SL, Shinnar RC, Sun S, FEBSTAT study team (2012) Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study. Epilepsia 53(9):1481–1488

    Article  CAS  Google Scholar 

  • Gershon AA (2017) Is chickenpox so bad, what do we know about immunity to varicella zoster virus, and what does it tell us about the future? J Infect 74(1):S27–S33

    Article  Google Scholar 

  • Gnann JW Jr, Whitley RJ (2017) Herpes simplex encephalitis: an Update. Curr Infect Dis Rep 19(3):13. https://doi.org/10.1007/s11908-017-0568-7. Review

    Article  PubMed  Google Scholar 

  • Grote V, von Kries R, Rosenfeld E, Belohradsky BH, Liese J (2007) Immunocompetent children account for the majority of complications in childhood herpes zoster. J Infect Dis 196(10):1455–1458

    Article  Google Scholar 

  • Gunkel J, de Vries LS, Jongmans M, Koopman-Esseboom C, van Haastert IC, Eijsermans MCJ, van Stam C, van Zanten BGA, Wolfs TFW, Nijman J (2018) Outcome of preterm infants with postnatal cytomegalovirus infection. Pediatrics 141:e20170635

    Article  Google Scholar 

  • Jenson HB (2000) Acute complications of Epstein-Barr virus infectious mononucleosis. Curr Opin Pediatr 12:263–268

    Article  CAS  Google Scholar 

  • Kennedy PGE, Gershon AA (2018) Clinical features of Varicella-Zoster Virus infection. Viruses 10(11):pii: E609

    Article  Google Scholar 

  • Kimberlin DW, Jester PM, Ster PM et al (2015) Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med 372(10):933–943

    Article  CAS  Google Scholar 

  • Leroy S, Moshous D, Cassar O, et al (2012) Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review. Pediatrics 129(1):e199–e203

    Article  Google Scholar 

  • Luck SE, Wieringa JW, Blázquez-Gamero D (2017) Congenital cytomegalovirus: a European expert consensus statement on diagnosis and management. Pediatr Infect Dis J 36(12):1205–1213

    Article  Google Scholar 

  • Okuno Y, Murata T, Sato Y, et al (2019) Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Nat Microbiol 4(3):404–413

    Article  Google Scholar 

  • Pellett Madan R, Allen UD, Green M, Höcker B, Michaels MG, Varela-Fascinetto G, Danziger-Isakov L (2018) Pediatric subgroup for the international consensus guidelines on the management of cytomegalovirus in solid organ transplantation and the international pediatric transplant association infectious disease committee. Pediatric transplantation case conference: update on cytomegalovirus. Pediatr Transplant 22(7):e13276

    Article  Google Scholar 

  • Rawlinson WD et al (2017) Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis 17(6):e177–e188

    Article  Google Scholar 

  • Revello MG, Lazzarotto T, Guerra B, Spinillo A, Ferrazzi E, Kustermann A, Guaschino S, Vergani P, Todros T, Frusca T, Arossa A, Furione M, Rognoni V, Rizzo N, Gabrielli L, Klersy C, Gerna G, CHIP Study Group (2014) A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus. N Engl J Med 370:1316–1326

    Article  CAS  Google Scholar 

  • Schuster V et al (2018) Herpes-simplex-Virus-Infektionen. In: DGPI-Handbuch Infektionen bei Kindern und Jugendlichen (Hrsg), 7., vollst. überarb. Aufl. Thieme-Verlag

    Google Scholar 

  • Streng A, Grote V, Rack-Hoch A, Liese JG (2017) Decline of neurologic varicella complications in children during the first seven years after introduction of universal varicella vaccination in Germany, 2005–2011. Pediatr Infect Dis J 36(1):79–86

    Article  Google Scholar 

  • Taylor GS, Long HM, Brooks JM, Rickinson AB, Hislop AD (2015) The immunology of Epstein-Barr virus-induced disease. Annu Rev Immunol 33:787–821

    Article  CAS  Google Scholar 

  • Townsend CL, Forsgren M, Ahlfors K, Ivarsson SA, Tookey PA, Peckham CS (2013) Long-term outcomes of congenital cytomegalovirus infection in Sweden and the United Kingdom. Clin Infect Dis 56:1232–1239

    Article  Google Scholar 

  • Vadoothker S, Andrews L, Jeng BH, Levin MR (2018) Management of Herpes Simplex Virus Keratitis in the pediatric population. Pediatr Infect Dis J 37(9):949–951

    PubMed  Google Scholar 

  • Wang C, Zhang X, Bialek S, Cannon MJ (2011) Attribution of congenital cytomegalovirus infection to primary versus non-primary maternal infection. Clin Infect Dis 52:e11–e13

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsklinikum Leipzig, Universitätsklinik für Kinder und Jugendliche, Leipzig, Deutschland

    Volker Schuster

  2. Universitätsklinikum Würzburg Kinderklinik und Poliklinik, Würzburg, Deutschland

    Hans-Wolfgang Kreth

  3. Universität Zürich, Zürich, Schweiz

    David Nadal

Authors
  1. Volker Schuster
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hans-Wolfgang Kreth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. David Nadal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Volker Schuster .

Editor information

Editors and Affiliations

  1. Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Heidelberg, Heidelberg, Germany

    Georg F. Hoffmann

  2. Bonn, Germany

    Michael J. Lentze

  3. Sinzheim, Rheinland-Pfalz, Germany

    Jürgen Spranger

  4. Zentrum für Kinder- und Jugendmedizin, Universitätsmedizin Mainz, Mainz, Germany

    Fred Zepp

  5. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden, Dresden, Germany

    Reinhard Berner

Section Editor information

  1. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus Dresden an der Technischen Universität Dresden, Dresden, Deutschland

    Reinhard Berner

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Schuster, V., Kreth, HW., Nadal, D. (2019). Herpesvirus-Infektionen bei Kindern und Jugendlichen. In: Hoffmann, G., Lentze, M., Spranger, J., Zepp, F., Berner, R. (eds) Pädiatrie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54671-6_370-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54671-6_370-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54671-6

  • Online ISBN: 978-3-642-54671-6

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Search

Navigation