Definition
A vaccine should activate a unique lymphocyte (B and/or T cell) response, which has an immediate antitumor effect as well as memory response against future tumor challenge (Fig. 1). The primary role of a cancer vaccine is the treatment of cancer or prevention of recurrence in a patient with surgically resected cancer, rather than “prevention” of cancer in a person who has never had cancer. Therefore, cancer vaccines are not thought of in the traditional sense of vaccines that are used for infectious diseases. If the current cancer vaccines prove to be useful in the above respects, then they may have a future role in preventing cancer in persons who have never had cancer but are at high risk for a particular type of cancer.
T-cell activation. T-cells recognize antigens as fragments of proteins (peptides) presented with major histocompatibility complex (MHC) molecules on the surface of cells. The antigen presenting cell processes exogenous protein from the vaccine or...
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References
Bhattacharya-Chatterjee M, Chatterjee SK, Foon KA (2002) Anti-idiotype antibody vaccine therapy for cancer. Expert Opin Biol Ther 2:869–881
Dalgleish AG, Whelan MA (2006) Cancer vaccines as a therapeutic modality: the long trek. Cancer Immunol Immunother 55:1025–1032
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Saha A, Chatterjee SK, Mohanty K et al (2003) Dendritic cell based vaccines for immunotherapy of cancer. Cancer Ther 1:299–314
See Also
(2012) BCG. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 356. doi: 10.1007/978-3-642-16483-5_560
(2012) FcR. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1386. doi: 10.1007/978-3-642-16483-5_2135
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Bhattacharya-Chatterjee, M., Chatterjee, S.K., Saha, A., Foon, K.A. (2014). Cancer Vaccines. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_819-4
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DOI: https://doi.org/10.1007/978-3-642-27841-9_819-4
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