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Encyclopedia of Cancer pp 1–4Cite as

Stromagenesis

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Synonyms

Desmoplasia; Desmoplastic Tumor Microenvironment; Oncofetal stroma; Stromal progression; Stromatogenesis; Tumor-associated stromal progression

Definition

Stromagenesis, from the Greek term stromatogenesis (yστρω\hskip-5pt\acute\\, μα stroma = mattress and γε\hskip-2.5pt\acute\; νɛσις genesis = creation or birth), is used to describe the progressive changes that stroma undergoes during the process of epithelial tumorigenesis. Specifically, the term describes tumor-associated changes in fibroblasts and fibroblast-derived extracellular matrix (also known as Desmoplasia), as opposed to the formation of new stromal endothelial blood vessels, identified as angiogenesis.

Characteristics

Although the term “stromagenesis” has only recently entered the scientific literature (2002) describing melanoma-fibroblast cross talk, the process of stromagenesis (or Desmoplasia) has been investigated for more than a century. Early publications from several pathologists in the late nineteenth...

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References

  • Beacham DA, Cukierman E (2005) Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression. Semin Cancer Biol 15:329–341

    Article  PubMed  Google Scholar 

  • Mintz B, Illmensee K (1975) Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci U S A 72:3585–3589

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 133:571–573

    Article  Google Scholar 

  • Ruiter D, Bogenrieder T, Elder D et al (2002) Melanoma-stroma interactions: structural and functional aspects. Lancet Oncol 3:35–43

    Article  PubMed  CAS  Google Scholar 

  • Soto AM, Sonnenschein C (2005) Emergentism as a default: cancer as a problem of tissue organization. J Biosci 30:103–118

    Article  PubMed  CAS  Google Scholar 

See Also

  • (2012) Extracellular matrix. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1362. doi:10.1007/978-3-642-16483-5_2067

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  • (2012) Familial adenomatous polyposis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1373. doi:10.1007/978-3-642-16483-5_2106

    Google Scholar 

  • (2012) Mosaic. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2373. doi:10.1007/978-3-642-16483-5_3838

    Google Scholar 

  • (2012) Stroma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3541. doi:10.1007/978-3-642-16483-5_5532

    Google Scholar 

  • (2012) Teratocarcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3651. doi:10.1007/978-3-642-16483-5_5729

    Google Scholar 

  • (2012) TGF-β. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3661. doi:10.1007/978-3-642-16483-5_5753

    Google Scholar 

  • (2012) Tumorigenesis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3815. doi:10.1007/978-3-642-16483-5_6063

    Google Scholar 

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Author information

Authors and Affiliations

  1. Basic Science/Tumor Cell Biology, Fox Chase Cancer Center, Philadelphia, PA, USA

    Edna Cukierman

Authors
  1. Edna Cukierman
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Corresponding author

Correspondence to Edna Cukierman .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Cukierman, E. (2014). Stromagenesis. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5533-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5533-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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