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Inhibition of Lipid Oxidation

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Drug Discovery and Evaluation: Pharmacological Assays

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Abstract

Oxidative modification of the low-density lipoproteins (LDL) has been shown to cause accelerated degradation of LDL via the scavenger receptor pathway. Under conditions of high serum LDL levels, LDL particles can migrate into the subendothelial space where oxidation of LDL can occur (Heinecke 1998; Jiang et al. 2011). The actual oxidation process is believed to begin with lipid peroxidation, followed by fragmentation to result in short-chain aldehydes. These aldehydes can form adducts with the lysine residues of apo B, creating a new epitope which is recognized by the scavenger receptor of macrophages.

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Author information

Authors and Affiliations

  1. Department of Physiology, UMR CNRS 7213, Université de Strasbourg, 74 route du Rhin, CS 60024, 67401 Cedex, Illkirch, France

    Philippe Boucher

  2. Johann Wolfgang Goethe-Universität Frankfurt am Main, Senckenberganlage 31, 60325, Frankfurt am Main, Germany

    Hans Gerhard Vogel

Authors
  1. Philippe Boucher
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  2. Hans Gerhard Vogel
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Corresponding author

Correspondence to Philippe Boucher .

Editor information

Editors and Affiliations

  1. Dieburg, Germany

    Franz J. Hock

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Boucher, P., Vogel, H.G. (2015). Inhibition of Lipid Oxidation. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_51-1

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  • DOI: https://doi.org/10.1007/978-3-642-27728-3_51-1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27728-3

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