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Lysophosphatidylcholine

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Encyclopedia of Cancer

Synonyms

Lysolecithin

Definition

Lysophosphatidylcholine (LPC) is a major plasma lipid constituent that is produced from phosphatidylcholine (PC).

Characteristics

LPC is produced from PC under a variety of physiological and pathological conditions. LPC is present at high levels (about 100 Î¼M) in plasma under normal conditions and exists mainly in albumin- or lipoprotein-bound forms. The biochemical conversion from PC to LPC is mediated by phospholipase A1 or phospholipase A2. Sequentially, LPC is converted to lysophosphatidate (LPA) by lysophospholipase D (autotaxin) (Fig. 1).

Lysophosphatidylcholine. Fig. 1
figure 1239 figure 1239

Metabolism of lysophosphatidylcholine

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References

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Author information

Authors and Affiliations

  1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea

    Geum-Youn Gwak

  2. Department of Internal Medicine, Seoul National University College of Medicine, Chongno-gu, Seoul, South Korea

    Jung-Hwan Yoon

Authors
  1. Geum-Youn Gwak
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  2. Jung-Hwan Yoon
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Corresponding author

Correspondence to Geum-Youn Gwak .

Editor information

Editors and Affiliations

  1. University Professor of Genetics, German Cancer Research Center - DKFZ, Heidelberg, Germany

    Manfred Schwab

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© 2011 Springer-Verlag Berlin Heidelberg

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Gwak, GY., Yoon, JH. (2011). Lysophosphatidylcholine. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_3471

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