Striatal-Enriched Protein-Tyrosine Phosphatase (STEP)

Kurup, Pradeep; Xu, Jian; Chatterjee, Manavi; Goebel-Goody, Susan; Paul, Surojit; Lombroso, Paul

doi:10.1007/978-3-319-67199-4_630

Striatal-Enriched Protein-Tyrosine Phosphatase (STEP)

Pradeep Kurup²,
Jian Xu²,
Manavi Chatterjee²,
Susan Goebel-Goody²,
Surojit Paul^2,3 &
…
Paul Lombroso²

Reference work entry
First Online: 01 January 2018

228 Accesses

Synonyms

Neural-specific protein-tyrosine phosphatase; Protein-tyrosine phosphatase, nonreceptor type 5 (striatum enriched); Protein-tyrosine phosphatase striatum enriched; PTPN5; PTPSTEP; STEP; Protein-tyrosine phosphatase nonreceptor type 5

Historical Background

Protein-tyrosine phosphatases (PTPs) play a significant role in diverse signaling mechanisms ranging from cellular differentiation to synaptic plasticity (Paul and Lombroso 2003; Tonks 2006). STriatal-Enriched protein-tyrosine Phosphatase (STEP) is a brain-specific protein tyrosine phosphatase belonging to the non-receptor tyrosine phosphatase family. Although enriched in the striatum, it is also localized to neurons in the cortex, hippocampus, and related brain regions (Boulanger et al. 1995). Interestingly, it is absent in the cerebellum, where a highly related PTP, PTP-STEP-like, is present (Watanabe et al. 1998). STEP exists as two major isoforms, named after their mobility in SDS-PAGE and designated STEP₆₁ and STEP₄₆....

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Child Study Center, Yale University, School of Medicine, New Haven, CT, 06473, USA
Pradeep Kurup, Jian Xu, Manavi Chatterjee, Susan Goebel-Goody, Surojit Paul & Paul Lombroso
Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA
Surojit Paul

Authors

Pradeep Kurup
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Jian Xu
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Manavi Chatterjee
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Susan Goebel-Goody
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Surojit Paul
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Paul Lombroso
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Corresponding author

Correspondence to Paul Lombroso .

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Editors and Affiliations

Department of Molecular Science and Technology, Ajou University, Suwon, Korea
Sangdun Choi

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Kurup, P., Xu, J., Chatterjee, M., Goebel-Goody, S., Paul, S., Lombroso, P. (2018). Striatal-Enriched Protein-Tyrosine Phosphatase (STEP). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_630

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DOI: https://doi.org/10.1007/978-3-319-67199-4_630
Published: 01 June 2018
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences

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