Synonyms
Historical Background
Synaptotagmin-like proteins (Slps) were originally identified as synaptotagmin-related molecules containing two C2 calcium/phospholipid-binding motifs (named the C2A domain and the C2B domain) at their C terminus and no transmembrane domain at their N terminus (Fig. 1a), which suggested that they regulate certain intracellular membrane traffic events, the same as synaptotagmin I (Syt I) does in synaptic vesicle traffic (Fukuda and Mikoshiba 2001). The Slp family of proteins is now defined as a family of proteins, each of which contains an N-terminal conserved motif named the Slp homology domain (SHD) (Fig. 1a, magenta boxes) and C-terminal tandem C2 domains, although some members of the Slp family have several isoforms (e.g., Slp2-b, Slp3-b, and Slp4-b) that lack one of these domains because of alternative splicing (Fig. 1a, bars and arrows) (Fukuda et al. 2001). The Slp family is also recognized as the third group of...
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Fukuda, M. (2018). Slp (Synaptotagmin-Like Protein). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_560
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DOI: https://doi.org/10.1007/978-3-319-67199-4_560
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