Historical Background
The contraction and relaxation of skeletal muscle is regulated by the concomitant rise and fall of the cytoplasmic calcium level. The Ca2+ is released from the sarcoplasmic reticulum by ryanodine receptor and taken back to the SR by SERCA pumps. The idea of a relaxing factor had been put forward for a long time by many researchers seeking for control mechanism of muscle function. The successful candidate was found in a high-speed pellet of rabbit white skeletal muscle capable of hydrolyzing ATP in Ca2+- and Mg2+-dependent manner and requiring the presence of phospholipids. The dependence on phospholipids and incompatibility to detergents implicated that self-forming sealed vesicles accumulated calcium...
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Zádor, E., Kósa, M. (2018). Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101795
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101795
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