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Tenascin-W (Tnn, TNN)

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

Tenascin-N

Historical Background

Tenascins are glycoproteins found in the extracellular matrix of chordates (Chiquet-Ehrismann and Tucker 2011). Near their N-terminus tenascins have heptad repeats that support trimerization, and two trimers can be bound by disulfide bridges spanning N-terminal domains to form a hexabrachion. The N-terminal region is followed by one or more epidermal growth factor (EGF)-like domains that have a distinctive arrangement of cysteine residues (****C***C*****C****C*C********C). These are followed by a string of fibronectin type III (FNIII) domains and a C-terminal fibrinogen-related domain.

The original tenascin is tenascin-C (the “C” stands for cytotactin, a name given to this tenascin by one of its codiscoverers). Tenascin-C is the best studied of the tenascins and is prominently expressed in the embryo at sites of cell migration, epithelial-mesenchymal interactions, and in developing connective tissue. In the adult, tenascin-C is found at the...

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References

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Author information

Authors and Affiliations

  1. Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern, CH-3010, Bern, Switzerland

    Martin Degen

  2. Department of Cell Biology and Human Anatomy, University of California, Davis, CA, 95818, USA

    Richard P. Tucker

Authors
  1. Martin Degen
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  2. Richard P. Tucker
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Corresponding author

Correspondence to Richard P. Tucker .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Degen, M., Tucker, R.P. (2018). Tenascin-W (Tnn, TNN). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101623

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