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MicroRNA-125b Modulates Inflammatory Chemokine CCL4 Expression and Its Reduction May Cause CCL4 Increase in Circulation with Age

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Handbook of Immunosenescence

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Abstract

Elevated levels of inflammatory chemokines in circulation are a hallmark of aging, but the mechanisms underlying this age-associated change are not fully understood. Recent studies suggest microRNAs play a role in the regulation of chemokine expression. Here, we review the current understanding of expression of inflammatory CC chemokine ligand 4 (CCL4) in human immune cells and its increase with aging and how reduction of microRNA-125b (miR-125b) expression contributes to the increase of CCL4 in monocytes and naïve CD8+ T cells in old adults.

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Authors and Affiliations

  1. Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Nai-Lin Cheng

  2. Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA

    Nan-ping Weng

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  1. Nai-Lin Cheng
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  2. Nan-ping Weng
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Correspondence to Nan-ping Weng .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, Québec, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Cheng, NL., Weng, Np. (2018). MicroRNA-125b Modulates Inflammatory Chemokine CCL4 Expression and Its Reduction May Cause CCL4 Increase in Circulation with Age. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_108-1

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